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首页> 外文期刊>Sport sciences for health >Platelet rich plasma intra-articular injections: a new therapeutic strategy for the treatment of knee osteoarthritis in sport rehabilitation. A systematic review
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Platelet rich plasma intra-articular injections: a new therapeutic strategy for the treatment of knee osteoarthritis in sport rehabilitation. A systematic review

机译：富含血小板的血浆关节腔内注射：运动康复治疗膝骨关节炎的新治疗策略。系统评价

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摘要

Osteoarthritis (OA) is the most common joint disease and the prevalence of knee OA among athletes is higher than in the general population, especially after injury or in association with high-impact sport. We evaluated the clinical evidence and the persistence of the beneficial effects of intraarticular injections of platelet-rich plasma (PRP) in patients affected by knee OA. A systematic computerized literature search of following databases was conducted: PubMed, Medline, Cochrane, CINAHL, Embase, SportDiscus, Pedro and Google scholar. PRP has been shown to be an effective and well-tolerated treatment option in OA, with greater and longer effects in young men with a low degree of cartilage degeneration. The role of growth factors and inflammatory mediators in the pathophysiology of OA suggest that PRP may be useful in the early stages to modulate inflammatory processes. Although current studies are encouraging, more data and long-term follow-up are required before PRP can be recommended in the treatment of OA. Future PRP research should involve questions regarding the mechanism of actions, formulation, and number and timing of injections to better identify patient selection criteria.
机译：骨关节炎（OA）是最常见的关节疾病，并且运动员中膝盖OA的患病率高于一般人群，尤其是在受伤后或与高强度运动有关的情况下。我们评估了临床证据以及关节内注射富血小板血浆（PRP）对膝骨关节炎患者的有益效果的持久性。对以下数据库进行了系统的计算机化文献检索：PubMed，Medline，Cochrane，CINAHL，Embase，SportDiscus，Pedro和Google Scholar。 PRP已被证明是OA中一种有效且耐受性良好的治疗选择，在软骨变性程度较低的年轻男性中，作用越来越大。生长因子和炎症介质在OA病理生理中的作用表明，PRP在早期调节炎症过程中可能有用。尽管当前的研究令人鼓舞，但在推荐使用PRP治疗OA之前，需要更多的数据和长期随访。未来的PRP研究应涉及有关作用机理，制剂，注射次数和时机的问题，以更好地确定患者选择标准。

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