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首页> 外文期刊>Prostaglandins, Leukotrienes, and Essential Fatty Acids >Studies on the protective effect of dietary fish oil on uranyl-nitrate-induced nephrotoxicity and oxidative damage in rat kidney.
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Studies on the protective effect of dietary fish oil on uranyl-nitrate-induced nephrotoxicity and oxidative damage in rat kidney.

机译：日粮鱼油对硝酸铀酰诱导的大鼠肾脏肾毒性和氧化损伤的保护作用研究。

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摘要

Human and animal exposure demonstrates that uranium is nephrotoxic. However, attempts to reduce it were not found suitable for clinical use. Dietary fish oil (FO) enriched in omega-3 fatty acids reduces the severity of cardiovascular and renal diseases. Present study investigates the protective effect of FO on uranyl nitrate (UN)-induced renal damage. Rats prefed with experimental diets for 15 days, given single nephrotoxic dose of UN (0.5mg/kg body weight) intraperitoneally. After 5d of UN treatment, serum/urine parameters, enzymes of carbohydrate metabolism, brush border membrane (BBM), oxidative stress and phosphate transport were analyzed in rat kidney. UN nephrotoxicity was characterized by increased serum creatinine and blood urea nitrogen. UN increased the activity of lactate dehydrogenase and NADP-malic enzyme whereas decreased malate, isocitrate and glucose-6-phophate dehydrogenases; glucose-6-phophatase, fructose-1, 6-bisphosphatase and BBM enzyme activities. UN caused oxidant/antioxidant imbalances as reflected by increased lipid peroxidation, activities of superoxide dismutase, glutathione peroxidase and decreased catalase activity. Feeding FO alone increased activities of enzymes of glucose metabolism, BBM, oxidative stress and Pi transport. UN-elicited alterations were prevented by FO feeding. However, corn oil had no such effects and was not similarly effective. In conclusion, FO appears to protect against UN-induced nephrotoxicity by improving energy metabolism and antioxidant defense mechanism.
机译：人和动物的暴露表明铀具有肾毒性。但是，发现减少它的尝试不适合临床使用。富含omega-3脂肪酸的膳食鱼油（FO）降低了心血管和肾脏疾病的严重程度。本研究调查了FO对硝酸铀酰（UN）引起的肾脏损害的保护作用。大鼠腹腔内给予实验性饮食15天，给予单一肾毒性剂量的UN（0.5mg / kg体重）。联合国治疗5天后，分析了大鼠肾脏的血清/尿液参数，碳水化合物代谢酶，刷状缘膜（BBM），氧化应激和磷酸盐转运。联合国肾毒性的特征是血清肌酐和血液尿素氮增加。联合国增加了乳酸脱氢酶和NADP-苹果酸酶的活性，而减少了苹果酸，异柠檬酸和葡萄糖-6-磷酸脱氢酶的活性。葡萄糖6-磷酸酶，果糖-1、6-双磷酸酶和BBM酶活性。联合国造成的氧化剂/抗氧化剂失衡表现为脂质过氧化增加，超氧化物歧化酶活性，谷胱甘肽过氧化物酶活性和过氧化氢酶活性降低。单独喂食FO会增加葡萄糖代谢，BBM，氧化应激和Pi转运的酶活性。 FO喂养防止了联合国引起的改变。但是，玉米油没有这种作用，并且没有类似的效果。总之，FO似乎可以通过改善能量代谢和抗氧化剂防御机制来预防联合国诱发的肾毒性。

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