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首页> 外文期刊>Public Health Nutrition >Longitudinal growth of infants born to HIV-1-infected mothers in Belo Horizonte, Brazil.
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Longitudinal growth of infants born to HIV-1-infected mothers in Belo Horizonte, Brazil.

机译：巴西贝洛奥里藏特的HIV-1感染母亲所生婴儿的纵向生长。

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Objective: To prospectively evaluate growth parameters assessed by weight and length in infected and uninfected infants born to HIV-1-infected mothers and followed from birth to 18 months. Methods: A cohort consisting of ninety-seven uninfected and forty-two infected infants born to HIV-infected mothers enrolled from 1995 to 2004, and admitted during their first 3 months of life at a referral Pediatric AIDS Clinic in Belo Horizonte, Brazil. Infants were followed until 18 months of age. Data were analysed using mixed-effects linear regression models for weight and length fitted by restricted maximum likelihood. Results: Infected infants contributed to 466 weight and 411 recumbent length measurements. Uninfected infants provided 924 weight and 907 length measurements. Mean birth weight and length were similar in both groups, 3.1 (SD 0.4) and 3.0 (SD 0.5) kg, and 48.7 (SD 1.4) and 48.8 (SD 2.9) cm for uninfected and infected infants, respectively. However, HIV-1 infection had an early impact in growth impairment: at 6 months of age, HIV-infected children were 1 kg lighter and 2 cm shorter than the uninfected. Conclusions: Growth faltering in weight, but not length, in HIV-infected children in Brazil is more marked than that reported in a European cohort, probably reflecting background nutritional deficiencies and concomitant infections. In these settings, early and aggressive nutritional management in HIV-1-infected infants should be a priority intervention associated with the antiretroviral therapy.
机译：目的：前瞻性评估以体重和身长评估的感染HIV和未感染HIV的母亲所生的婴儿的生长参数，这些婴儿由出生至18个月。方法：研究对象是1995年至2004年之间由HIV感染的母亲所生的97例未感染婴儿和42例感染婴儿组成的队列，他们在出生后的头三个月进入巴西贝洛哈里桑塔的儿科艾滋病诊所就诊。婴儿被追踪至18个月大。使用混合效应线性回归模型对数据进行分析，以得出重量和长度受限制的最大似然拟合。结果：被感染的婴儿有助于测量466体重和411靠背长度。未感染的婴儿提供了924体重和907长度的测量。两组的平均出生体重和身长相似，分别为3.1（SD 0.4）和3.0（SD 0.5）kg，未感染和感染婴儿分别为48.7（SD 1.4）和48.8（SD 2.9）cm。但是，HIV-1感染对生长障碍有早期影响：在6个月大时，被HIV感染的儿童比未感染的儿童轻1 kg，短2 cm。结论：在巴西，被艾滋病毒感染的儿童的体重增长缓慢，但没有步伐，其增长步伐比欧洲队列报告的更为明显，这可能反映了背景营养缺乏和伴随感染。在这些情况下，应将与HIV-1感染婴儿的早期和积极营养管理作为与抗逆转录病毒疗法相关的优先干预措施。

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