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首页> 外文期刊>Public Health Nutrition >The duration of obesity and the risk of type 2 diabetes. (Special Issue: Overweight and obesity.)
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The duration of obesity and the risk of type 2 diabetes. (Special Issue: Overweight and obesity.)

机译：肥胖的持续时间和2型糖尿病的风险。 （特刊：超重和肥胖。）

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Objective: The evidence for the association between obesity and the risk of type 2 diabetes has been derived mainly from the analysis of the degree of obesity. The role of the duration of obesity as an independent risk has not been fully explored. The objective of the present study was to investigate the association between the duration of obesity and the risk of type 2 diabetes. Design: Prospective cohort study. Setting: The Framingham Heart Study (FHS), follow-up from 1948 to 1998. Subjects: A total of 1256 FHS participants who were free from type 2 diabetes at baseline, but were obese on at least two consecutive of the study's twenty-four biennial examinations, were included. Type 2 diabetes status was collected throughout the 48 years of follow-up of the study. The relationship between duration of obesity and type 2 diabetes was analysed using time-dependent Cox models, adjusting for a number of covariates. Results: The unadjusted hazard ratio (HR) for the risk of type 2 diabetes for men was 1.13 (95% CI 1.09, 1.17) and for women was 1.12 (95% CI 1.08, 1.16) per additional 2-year increase in the duration of obesity. Adjustment for sociodemographic variables, family history of diabetes, health behaviour and physical activity made little difference to these HR. For women the evidence of a dose-response relationship was less clear than for men, particularly for women with an older age at obesity onset. Conclusions: The duration of obesity is a relevant risk factor for type 2 diabetes, independent of the degree of BMI.Digital Object Identifier http://dx.doi.org/10.1017/S1368980010001813
机译：目的：肥胖与2型糖尿病风险之间关系的证据主要来自对肥胖程度的分析。肥胖持续时间作为独立风险的作用尚未得到充分研究。本研究的目的是研究肥胖持续时间与2型糖尿病风险之间的关系。设计：前瞻性队列研究。地点：弗雷明汉心脏研究（FHS），从1948年至1998年进行随访。受试者：共有1256名FHS参与者，他们在基线时没有2型糖尿病，但在该研究的24个研究中至少有两个连续肥胖每两年检查一次。在研究的整个48年中收集2型糖尿病状态。使用时间依赖性Cox模型分析肥胖持续时间与2型糖尿病之间的关系，并调整许多协变量。结果：每增加2年，男性2型糖尿病风险的未经调整风险比（HR）为1.13（95％CI 1.09，1.17），女性为1.12（95％CI 1.08，1.16）肥胖。对社会人口统计学变量，糖尿病家族史，健康行为和体育锻炼的调整对这些HR几乎没有影响。与男性相比，女性的剂量反应关系证据不明确，尤其是肥胖症发病年龄较大的女性。结论：肥胖持续时间是2型糖尿病的相关危险因素，与BMI的程度无关。数字对象标识符http://dx.doi.org/10.1017/S1368980010001813

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