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首页> 外文期刊>Psychiatry >The contribution of early traumatic events to schizophrenia in some patients: a traumagenic neurodevelopmental model.
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The contribution of early traumatic events to schizophrenia in some patients: a traumagenic neurodevelopmental model.

机译：在某些患者中，早期创伤事件对精神分裂症的贡献：创伤性神经发育模型。

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摘要

The current diathesis-stress model of schizophrenia proposes that a genetic deficit creates a predisposing vulnerability in the form of oversenstivity to stress. This model positions all psychosocial events on the stress side of the diathesis-stress equation. As an example of hypotheses that emerge when consideration is given to repositioning adverse life events as potential contributors to the diathesis, this article examines one possible explanation for the high prevalence of child abuse found in adults diagnosed schizophrenic. A traumagenic neurodevelopmental (TN) model of schizophrenia is presented, documenting the similarities between the effects of traumatic events on the developing brain and the biological abnormalities found in persons diagnosed with schizophrenia, including overreactivity of the hypothalamic-pituitary-adrenal (HPA) axis; dopamine, norepinephrine, and serotonin abnormalities; and structural changes to the brain such as hippocampal damage, cerebral atrophy, ventricular enlargement, and reversed cerebral asymmetry. The TN model offers potential explanations for other findings in schizophrenia research beyond oversensitivity to stress, including cognitive impairment, pathways to positive and negative symptoms, and the relationship between psychotic and dissociative symptomatology. It is recommended that clinicians and researchers explore the presence of early adverse life events in adults with psychotic symptoms in order to ensure comprehensive formulations and appropriate treatment plans, and to further investigate the hypotheses generated by the TN model.
机译：当前的精神分裂症的素质-压力模型提出，遗传缺陷以对压力的过度敏感性的形式产生了易感性。该模型将所有社会心理事件定位在素质-压力方程的压力侧。作为考虑到将不良生活事件重新定位为潜在影响因素的假说的一个例子，本文探讨了一种可能的解释，说明在诊断为精神分裂症的成人中儿童虐待的普遍性很高。提出了一种精神分裂症的创伤性神经发育（TN）模型，记录了创伤事件对发育中的大脑的影响与被诊断为精神分裂症的人所发现的生物学异常之间的相似性，包括下丘脑-垂体-肾上腺（HPA）轴反应过度;多巴胺，去甲肾上腺素和5-羟色胺异常;以及大脑的结构变化，例如海马体损伤，脑萎缩，心室扩大和逆向性脑不对称。 TN模型为精神分裂症研究中的其他发现提供了潜在的解释，除了对压力的过度敏感性外，包括认知障碍，阳性和阴性症状的途径以及精神病和解离症状之间的关系。建议临床医生和研究人员探讨患有精神病症状的成年人中早期不良生活事件的存在，以确保全面的配方和适当的治疗计划，并进一步研究TN模型产生的假设。

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