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Assessing clinical significance using robust normative comparisons

机译:使用可靠的规范比较评估临床意义

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Objective: Clinical significance determines whether an intervention makes a real difference in the everyday life of a client. One of the most recommended approaches for conducting group-level analyses of clinical significance is to evaluate whether the treated clinical group is equivalent to a normal comparison group (normative comparisons). The purpose of this study was to demonstrate the analytical and practical power of assessing clinical significance using normative comparisons that are robust to violations of normality and homogeneity of variance assumptions. Method: Six datasets were gleaned from published intervention studies for depression. Results: We found that normative comparisons using a robust Schuirmann-Yuen test determined equivalency for 11% fewer clinical samples compared to original normative comparisons that use a Schuirmann test of equivalence. Conclusions: We recommend that researchers conducting normative comparisons utilize the Schuirmann-Yuen procedure as it provides the most reliable method available for determining if a treated clinical group is equivalent to a normative comparison group.
机译:目的:临床意义决定了一项干预措施能否真正改变患者的日常生活。进行临床意义上的组水平分析的最推荐方法之一是评估所治疗的临床组是否等同于正常对照组(规范比较)。这项研究的目的是展示使用规范性比较评估临床意义的分析和实践能力,该规范性比较对于违反正态性和方差假设的同质性具有鲁棒性。方法:从已发表的抑郁症干预研究中收集了六个数据集。结果:我们发现,与使用Schuirmann等效性检验的原始规范比较相比,使用健壮的Schuirmann-Yuen检验进行的规范性比较确定的等效性减少了11%的临床样本。结论:我们建议进行规范比较的研究人员使用Schuirmann-Yuen程序,因为它提供了最可靠的方法来确定治疗的临床组是否等同于规范比较组。

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