• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Psychopharmacology >Role of dopamine transporters in the behavioral effects of 3,4-methylenedioxymethamphetamine (MDMA) in nonhuman primates.
【24h】

Role of dopamine transporters in the behavioral effects of 3,4-methylenedioxymethamphetamine (MDMA) in nonhuman primates.

机译：多巴胺转运蛋白在非人类灵长类动物中3,4-亚甲基二氧基甲基苯丙胺（MDMA）的行为效应中的作用。

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

RATIONALE: The interoceptive and reinforcing effects of 3,4-methylenedioxymethamphetamine (MDMA) are similar to those of psychostimulants, but the role of dopamine in the behavioral effects of MDMA is not well documented, especially in primates. OBJECTIVE: The aim of this study was to assess the role of dopamine in the behavioral effects of MDMA in two nonhuman primate species. METHODS: The behavioral effects of MDMA, with and without serotonergic or dopaminergic pretreatments, were studied in squirrel monkeys trained to respond under a fixed-interval schedule of stimulus termination; effects on caudate dopamine levels were studied in a separate group of squirrel monkeys using in vivo microdialysis. Positron emission tomography neuroimaging with the dopamine transporter (DAT) ligand [18F]FECNT was used to determine DAT occupancy by MDMA in rhesus monkeys. RESULTS: MDMA (0.5-1.5 mg/kg) did not induce behavioral stimulant effects, but the highest dose of MDMA suppressed responding. Pretreatment with fluoxetine (3.0 mg/kg) or the selective 5HT(2A) antagonist M100907 (0.03-0.3 mg/kg) attenuated the rate suppressing effects of MDMA. In contrast, pretreatment with the selective dopamine transporter inhibitor RTI-177 (0.1 mg/kg) did not alter the rate suppressing effects of MDMA. Administration of MDMA at a dose that suppressed operant behavior had negligible effects on extracellular dopamine. The percent DAT occupancy of MDMA at a dose that suppressed operant behavior also was marginal and reflected low in vivo potency for DAT binding. CONCLUSIONS: Collectively, these results indicate that behaviorally relevant doses of MDMA do not induce behavioral stimulant or dopamine transporter-mediated effects in nonhuman primates.
机译：理由：3,4-亚甲二氧基甲基苯丙胺（MDMA）的互感和增强作用与精神兴奋剂相似，但是多巴胺在MDMA行为作用中的作用尚未得到充分证明，特别是在灵长类动物中。目的：本研究的目的是评估多巴胺在两种非人类灵长类动物的MDMA行为影响中的作用。方法：在固定间隔时间的刺激终止训练下，对接受或不接受血清素能或多巴胺能预处理的MDMA的行为效应进行了研究。在另一组松鼠猴中，通过体内微透析研究了对尾巴多巴胺水平的影响。用多巴胺转运蛋白（DAT）配体[18F] FECNT进行正电子发射断层扫描神经成像，以测定MDMA在恒河猴中的DAT占用率。结果：摇头丸（0.5-1.5 mg / kg）不会引起行为刺激作用，但是摇头丸的最高剂量抑制了反应。用氟西汀（3.0 mg / kg）或选择性5HT（2A）拮抗剂M100907（0.03-0.3 mg / kg）进行的预处理减弱了MDMA的抑制率。相反，用选择性多巴胺转运蛋白抑制剂RTI-177（0.1 mg / kg）进行预处理不会改变MDMA的抑制率。以抑制手术者行为的剂量服用MDMA对细胞外多巴胺的影响可忽略不计。在抑制操作行为的剂量下，MDMA的DAT占用百分比也很小，反映了DAT结合的体内效力低。结论：总的来说，这些结果表明行为相关剂量的MDMA不会在非人类灵长类动物中诱发行为刺激或多巴胺转运蛋白介导的作用。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号