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Karl Pearson's meta analysis revisited

机译:卡尔·皮尔森的元分析再访

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It turns out that the method Birnbaum (Ref. 1) analyzed to conclude inadmissibility was not the one that Pearson proposed. Because it is admissible Pearson test has higher power than Fisher's standard test at some alternatives and lower power at others. Pearson's method has the advantage when all or most of the non-zero parameters share the same sign and it has proved useful in a genomic setting and screening for age- related genes. This paper also presents an FFT-based method for getting hard upper and lower bounds on the (DF of a sum of nonnegative random variables. (29 refs.)
机译:事实证明,Birnbaum(参考文献1)分析得出结论认为不可接受的方法不是Pearson提出的。因为是允许的,所以Pearson测试在某些替代方案中具有比Fisher标准测试更高的功效,而在其他替代方案中具有更低的功效。当所有或大多数非零参数共享相同的符号时,Pearson方法具有优势,并且它已被证明可用于基因组设置和年龄相关基因的筛选。本文还提出了一种基于FFT的方法来获得(非负随机变量之和的DF的)硬上限和下限(29 refs。)

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