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首页> 外文期刊>Pulmonary pharmacology & therapeutics >Maternal influence in the transmission of asthma susceptibility.
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Maternal influence in the transmission of asthma susceptibility.

机译：孕产妇对哮喘易感性传播的影响。

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Asthma is one of the most common chronic diseases in children, with increasing morbidity and mortality. A genetic predisposition and exposure to allergens have been implicated as major risk factors for the development of asthma. However, increasing evidence indicates that the mother plays a crucial role in mediating the development of fetal-infant immune responses to inhaled allergens. The exact nature and mechanism of this maternal influence and how it might be associated with the development of allergic sensitization and asthma are not clear. Under normal conditions, the maternal environment during pregnancy promotes an initial Th2 skewed immune response in the offspring which transitions to a nonallergic Th1 type response after birth. However, the allergic mother's influence may delay the normal transition to a nonallergic immune response to inhaled allergens in her children, thus increasing the risk for the development of allergic sensitization and/or asthma. Understanding the underlying mechanismsby which the maternal immune environment can influence the development of the fetal-infant immune response to inhaled allergens may lead to identifying new targets for the prevention of allergic sensitization and asthma.
机译：哮喘是儿童中最常见的慢性疾病之一，发病率和死亡率不断增加。遗传易感性和接触过敏原被认为是哮喘发展的主要危险因素。但是，越来越多的证据表明，母亲在介导胎儿对吸入性变应原的免疫反应的发展中起着至关重要的作用。尚不清楚这种母体影响的确切性质和机制，以及它可能与过敏性致敏和哮喘的发展有关。在正常情况下，怀孕期间的孕产妇环境会促进后代中最初的Th2偏向免疫反应，并在出生后转变为非过敏性Th1型反应。但是，变态母亲的影响可能会延迟其孩子对吸入的变应原的正常转变为对变态反应的非变态免疫反应，从而增加了变态反应致敏和/或哮喘的风险。了解孕产妇的免疫环境可能影响胎儿对吸入的过敏原的免疫反应的发展的基本机制，可能会导致确定预防过敏性致敏和哮喘的新靶标。

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