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首页> 外文期刊>Pulmonary pharmacology & therapeutics >Sildenafil for pulmonary hypertension: Dose-dependent improvement in exercise performance.
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Sildenafil for pulmonary hypertension: Dose-dependent improvement in exercise performance.

机译：西地那非治疗肺动脉高压：运动表现的剂量依赖性改善。

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摘要

Sildenafil has been widely used as an orphan drug for several years, mostly at a dose of 50mg tid. Since a recent randomized study showed no dose-response relationship, the target dose in future will be 20mg tid. This might, however, have a negative effect on patients being already on 50mg tid. During the past years we usually up-titrated the sildenafil dosage in monthly intervals from 12.5 to 25mg, and then finally to 50mg tid. Therefore, we wondered if a dose-response relationship could be found in a group of 23 patients, in whom we had measured a 6-min walking distance (6-MWD) at all time points. The 6-MWD was virtually unchanged during the treatment with sildenafil 12.5 and 25mg tid, respectively. However, there was a significant improvement by 34+/-63 and 26+/-47m in the 6-MWD after increasing the sildenafil dose to 50mg tid compared with baseline (p=0.015) and 25mg tid (p=0.014), respectively. In conclusion, these data suggest that sildenafil has a clinically relevant dose-response relationship with a significant improvement in 6-MWD only at a dose of 50mg tid.
机译：西地那非已被广泛用作孤儿药已有好几年了，主要是剂量为50mg tid。由于最近的一项随机研究显示没有剂量反应关系，因此将来的目标剂量将为20mg tid。但是，这可能会对已经接受50mg每日两次的患者产生负面影响。在过去的几年中，我们通常将西地那非的剂量从每月12.5毫克提高到25毫克，然后最终到每日50毫克。因此，我们想知道是否可以在一组23位患者中找到剂量反应关系，他们在所有时间点都测量了6分钟的步行距离（6-MWD）。在用西地那非12.5和25mg tid处理期间，6-MWD几乎没有变化。但是，将西地那非剂量增加至50mg tid后，6-MWD分别较基线（p = 0.015）和25mg tid（p = 0.014）分别显着改善了34 +/- 63和26 +/- 47m。 。总之，这些数据表明西地那非具有临床相关的剂量反应关系，仅当剂量为50mg tid时，6-MWD才会显着改善。

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