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首页> 外文期刊>Pulmonary pharmacology & therapeutics >Sam So Eum, a herb extract, as the remedy for allergen-induced asthma in mice.
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Sam So Eum, a herb extract, as the remedy for allergen-induced asthma in mice.

机译：Sam So Eum，一种草药提取物，作为过敏原诱发的小鼠哮喘的药物。

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We studied administering Sam So Eum (SSE) as a herbal medicine to treat asthma in mice and we discussed the mechanism of restoring the immuno-modulating cytokines such as IL-10 and IFN-gammaThe mice treated with SSE did not show any significant variation in their body weight and they looked very similar to the controlled ones. The SSE-treated mice showed reduced levels of airway responsiveness to methacholine, and these levels were initially elevated by the induction of asthma compared to the control group. The SSE elevated production level of IFN-gamma, which was down-regulated upon induction of asthma. This result implies that SSE can change the Th1/Th2 ratio through Th1-skewing reactions, and that SSE can decrease airway hyperresponsiveness by changing the Th1/Th2 ratio. The treatment with SSE also restored the IL-10 level to that of the naive condition. This means that SSE reduced the airway inflammation through this pathway. The ovalbumin (OVA)-specific antibody (total Ig) production in the serum was also decreased upon SSE treatment. Prednisolone (PD) was used as positive control. The effectiveness of SSE was almost the same as that of PD. These results suggest the possibility of using SSE for the treatment of patients with asthma, and its therapeutic efficacy involves restoring the IFN-gamma and IL-10 levels.
机译：我们研究了将Sam So Eum（SSE）用作治疗小鼠哮喘的草药，并讨论了恢复免疫调节细胞因子（例如IL-10和IFN-γ）的机制。它们的体重和外观与对照组非常相似。经SSE处理的小鼠显示出对乙酰甲胆碱的气道反应性降低，并且与对照组相比，这些水平最初是通过诱发哮喘而升高的。 SSE提高了IFN-γ的产生水平，其在哮喘诱导后被下调。该结果暗示SSE可以通过Th1-偏斜反应改变Th1 / Th2比，并且SSE可以通过改变Th1 / Th2比来降低气道高反应性。用SSE进行的治疗还可以将IL-10水平恢复到初始状态。这意味着SSE通过该途径减少了气道炎症。 SSE处理后，血清中卵白蛋白（OVA）特异性抗体（总Ig）的产生也降低了。泼尼松龙（PD）用作阳性对照。 SSE的有效性几乎与PD相同。这些结果表明使用SSE治疗哮喘患者的可能性，其治疗功效涉及恢复IFN-γ和IL-10的水平。

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