Pharmacological characterization of the interaction between the dual phosphodiesterase (PDE) 3/4 inhibitor RPL554 and glycopyrronium on human isolated bronchi and small airways

Calzetta Luigino; Cazzola Mario; Page Clive P.; Rogliani Paola; Facciolo Francesco; Matera Maria Gabriella

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Pharmacological characterization of the interaction between the dual phosphodiesterase (PDE) 3/4 inhibitor RPL554 and glycopyrronium on human isolated bronchi and small airways

机译：双磷酸二酯酶（PDE）3/4抑制剂RPL554和格隆铵在人分离的支气管和小气道上相互作用的药理学表征

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Background: The dual PDE3/4 inhibitor RPL 554 causes bronchodilation in patients with asthma or COPD and synergistically interacts with muscarinic receptor antagonists in relaxing human isolated bronchi in acute experimental settings. In the present study we investigated the long-lasting interaction between RPL554 and glycopyrronium by testing these drugs for their ability to relax both medium and small human isolated bronchi.

机译：背景：双重PDE3 / 4抑制剂RPL 554在哮喘或COPD患者中导致支气管扩张，并在急性实验环境中与人毒蕈碱受体拮抗剂协同作用，使人分离的支气管舒张。在本研究中，我们通过测试RPL554和格隆溴铵在中小人体分离支气管中的松弛能力来研究它们之间的持久相互作用。

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《Pulmonary pharmacology & therapeutics》 |2015年第null期|共9页
作者
Calzetta Luigino; Cazzola Mario; Page Clive P.; Rogliani Paola; Facciolo Francesco; Matera Maria Gabriella;
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正文语种 eng
中图分类呼吸系及胸部疾病;
关键词
RPL554; Glycopyrronium; Synergistic interaction; Relaxant response; Human isolated bronchi; Small airways; Airway smooth muscle; Asthma; COPD;

机译：RPL554;甘草;协同相互作用;轻松反应;人离体支气管;小气道;气道平滑肌;哮喘;COPD;

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1. Pharmacological characterization of the interaction between the dual phosphodiesterase (PDE) 3/4 inhibitor RPL554 and glycopyrronium on human isolated bronchi and small airways [J] . Calzetta Luigino, Cazzola Mario, Page Clive P., Pulmonary pharmacology & therapeutics . 2015,第Null期

机译：双磷酸二酯酶（PDE）3/4抑制剂RPL554和格隆铵在人分离的支气管和小气道上相互作用的药理学表征
2. Pharmacological characterization of a novel phosphodiesterase type 5 (PDE5) inhibitor lodenafil carbonate on human and rabbit corpus cavernosum. [J] . Toque HA, Teixeira CE, Lorenzetti R, European Journal of Pharmacology: An International Journal . 2008,第1a3期

机译：新型磷酸二酯酶5型（PDE5）抑制剂洛地那非碳酸酯对人和兔海绵体的药理学表征。
3. Pharmacological characterization of the interaction between aclidinium bromide and formoterol fumarate on human isolated bronchi [J] . Cazzola Mario, Calzetta Luigino, Page Clive P., European Journal of Pharmacology: An International Journal . 2014,第Null期

机译：溴氰菊酯和富马酸福莫特罗对人分离支气管的相互作用的药理学表征
4. The Effects of Pharmacological Postconditioning with a Phosphodiesterase Type 3 Inhibitor Milrinone, and a Calcium Sensitizer Levosimendan [C] . Cho Sungsam, Matsumoto Shuhei, Sumikawa Koji ASEAN Congress of Anesthesiologists . 2009

机译：药理学后处理与磷酸二酯酶3抑制剂Milrinone的影响，以及钙敏化剂Levosimendan
5. Quaternary structure of human phosphodiesterase-11 (PDE11) isozymes and interaction of cyclic nucleotides and inhibitors with the catalytic site [D] . Weeks, James Louie, II 2008

机译：人磷酸二酯酶11（PDE11）同工酶的季结构以及环核苷酸和抑制剂与催化位点的相互作用
6. Pharmacological characterisation of the interaction between glycopyrronium bromide and indacaterol fumarate in human isolated bronchi small airways and bronchial epithelial cells [O] . Mario Cazzola, Luigino Calzetta, Ermanno Puxeddu, 2016

机译：格隆溴铵和富马酸茚达特罗在人体分离支气管小气道和支气管上皮细胞中相互作用的药理学表征
7. Pharmacological characterisation of the interaction between glycopyrronium bromide and indacaterol fumarate in human isolated bronchi, small airways and bronchial epithelial cells [O] . Cazzola, M, Calzetta, L, Puxeddu, E, 2016

机译：格隆溴铵和富马酸茚达特罗在人体分离支气管，小气道和支气管上皮细胞中相互作用的药理学表征

Pharmacological characterization of the interaction between the dual phosphodiesterase (PDE) 3/4 inhibitor RPL554 and glycopyrronium on human isolated bronchi and small airways

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