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首页> 外文期刊>Pulmonary pharmacology & therapeutics >GC-MS determined cotinine in an epidemiological study on smoking status at delivery.
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GC-MS determined cotinine in an epidemiological study on smoking status at delivery.

机译：GC-MS在关于分娩时吸烟状况的流行病学研究中确定了可替宁。

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The objective of this study was to measure the plasma cotinine levels in pregnant women and their newborns using a gas chromatography-mass spectrometry (GC-MS) method in an epidemiological-delivered population with a wide range of tobacco intakes. Nearly 1000 pregnant women from regional maternity wards (n=1007) were selected for the study. Each patient kept a tobacco diary and underwent a blood test to assess cotinine levels and at the same time that the newborns' cordonal plasma was taken. These values were then cross-checked. Cotinine was estimated using a selected-ion monitoring mode with a 1.5ng/ml quantification limit. The cotinine levels in mothers and newborns were highly correlated, whatever the mother's smoking status, with a calculated cut-off for cotinine levels in active smokers of 21.5ng/ml. Finally, the cotinine determined through this GC-MS method offered a sensitive and accurate measure of tobacco exposition of the pregnant women and their babies.
机译：这项研究的目的是使用流行病学调查的大量吸烟人群，通过气相色谱-质谱（GC-MS）方法测量孕妇及其新生儿的血浆可替宁水平。选择了来自区域产科病房（n = 1007）的近1000名孕妇。每位患者保留一份烟草日记，并进行血液检查以评估可替宁的水平，同时采集新生儿的脐带血浆。然后对这些值进行交叉检查。使用选择离子监测模式以1.5ng / ml的定量限估算可替宁。无论母亲的吸烟状况如何，母亲和新生儿中的可替宁水平高度相关，活动吸烟者的可替宁水平计算得出的临界值为21.5ng / ml。最后，通过这种GC-MS方法测定的可替宁可对孕妇及其婴儿的烟草暴露进行灵敏而准确的测量。

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