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Polyetheretherketone as a biomaterial for spinal applications

机译：聚醚醚酮作为脊柱应用的生物材料

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Threaded lumbar interbody spinal fusion devices (TIBFD) made from titanium have been reported to be 90% effective for single-level lumbar interbody fusion, although radiographic determination of fusion has been intensely debated in the literature. Using blinded radiographic, biomechanic, histologic, and statistical measures, we evaluated a radiolucent polyetheretherketone (PEEK)threaded interbody fusion device packed with autograft or rhBMP-2 on an absorbable collagen sponge in 13 sheep at 6 months. Radiographic fusion, increased spinal level biomechanical stiffness, and histologic fusion were demonstrated for the PEEK cages filled with autograft or rhBMP-2 on a collagen sponge. No device degradation or wear debris was observed. Only mild chronic inflammation consisting of a few macrophages was observed in peri-implant tissues. Based on these results, the polymeric biomaterial PEEK may be a useful biomaterial for interbody fusion cages due to the polymer's increased radiolucency and decreased stiffness. (c) 2005 Elsevier Ltd. All rights reserved.
机译：据报道，由钛制成的带螺纹的腰椎椎间融合器（TIBFD）对于单级腰椎椎间融合术具有90％的有效效果，尽管文献中对融合的放射线照相方法进行了激烈的争论。使用盲法的放射学，生物力学，组织学和统计学方法，我们在6个月时对13只绵羊的可吸收胶原海绵进行了放射线透亮的聚醚醚酮（PEEK）螺纹椎间融合器，其中装有自体移植或rhBMP-2。对于在胶原海绵上充满自体移植物或rhBMP-2的PEEK笼，证实了放射学融合，脊柱水平生物力学刚度增加和组织学融合。没有观察到器件退化或磨损碎片。在植入物周围组织中仅观察到由少量巨噬细胞组成的轻度慢性炎症。基于这些结果，由于聚合物的射线不透性增加和硬度降低，聚合物生物材料PEEK可能是用于椎间融合器的有用生物材料。 （c）2005 Elsevier Ltd.保留所有权利。

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