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首页> 外文期刊>Quimica nova >PREPARACAO E CARACTERIZACAO DE SUSPENSOES COLOIDAIS DE NANOCARREADORES LIPIDICOS CONTENDO RESVERATROL DESTINADOS A ADMINISTRACAO CUTANEA
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PREPARACAO E CARACTERIZACAO DE SUSPENSOES COLOIDAIS DE NANOCARREADORES LIPIDICOS CONTENDO RESVERATROL DESTINADOS A ADMINISTRACAO CUTANEA

机译：含白藜芦醇的脂质体纳米脂质体的胶体悬浮液的制备与表征

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摘要

Solid lipid nanoparticles (SLN), nanoemulsions (NE), and microemulsions (ME) were prepared by the hot solvent diffusion method, using tristearin or castor oil as oily phase, and soy lecithin and Solutol HS 15 as surfactants. Mean particle sizes ranged from 20 to 215 nm and negative zeta potentials were obtained for all nanocarriers. A HPLC method used to determine resveratrol was specific, linear, exact and precise. The entrapment efficiency was high for all formulations. However, resveratrol content was significantly varied among the lipid nanocarriers. Lipid nanocarrier containing hydrogels exhibiting pseudoplastic behavior were obtained after incorporation of hydroxyethylcellulose in the colloidal dispersions.
机译：采用三硬脂精或蓖麻油为油相，以大豆卵磷脂和Solutol HS 15为表面活性剂，通过热溶剂扩散法制备了固体脂质纳米颗粒（SLN），纳米乳剂（NE）和微乳剂（ME）。平均粒径范围为20至215 nm，所有纳米载体的Zeta电位均为负。用于测定白藜芦醇的HPLC方法具有特异性，线性，精确性和精确性。所有制剂的包封效率都很高。然而，白藜芦醇含量在脂质纳米载体之间显着变化。在胶态分散体中掺入羟乙基纤维素后，获得了具有假塑性行为的含脂质纳米载体的水凝胶。

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