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首页> 外文期刊>Psychiatry research >Serum prolactin levels in unmedicated first-episode and recurrent schizophrenia patients: a possible marker for the disease's subtypes.
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Serum prolactin levels in unmedicated first-episode and recurrent schizophrenia patients: a possible marker for the disease's subtypes.

机译：未经药物治疗的首发和复发型精神分裂症患者的血清催乳素水平：可能是该疾病亚型的标志物。

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Various studies indicate that we must consider schizophrenia not as a single disease but as several distinct etiological processes that give rise to characteristic symptoms. In the current study, we aimed to examine prolactin serum levels in unmedicated first-episode and recurrent schizophrenic patients. The prolactin levels were compared among the different schizophrenia subtypes, i.e. paranoid, schizoaffective and disorganized. Prolactin serum samples were assessed on the morning after the admission in 48 first-episode and 38 recurrent unmedicated hospitalized schizophrenia patients. Two psychiatrists made the diagnosis without knowledge of laboratory results and completed the rating scales. Despite all prolactin levels being within or close to the normal range, we found significant differences in prolactin serum levels among schizophrenia subtype patients: the lowest values were for the paranoid type, intermediate for the schizoaffective and the highest for the disorganized patients. The results seem to indicate a pronounced hyperdopaminergic activity in paranoid schizophrenia, suggesting differences in dopaminergic tone between the schizophrenia subtypes, and support the clinical and the neuropsychological individuality of disease subtypes. There were no significant differences in prolactin serum levels of the schizophrenia subtypes between the first-episode and the recurrent patients. It appears that there are constant patterns of dopamine bioactivity in acutely psychotic unmedicated schizophrenia patients, whether the patients are first admitted or recurrent.
机译：各种研究表明，我们必须将精神分裂症视为一种特征性症状，而不是将其视为一种疾病，而应将其视为一种疾病。在当前的研究中，我们旨在检查未经药物治疗的首发和复发性精神分裂症患者的催乳素血清水平。比较了不同精神分裂症亚型，即偏执狂，精神分裂症和杂乱无章的催乳素水平。入院后清晨评估催乳素血清样本，包括48例初发和38例复发性未治疗的住院精神分裂症患者。两名精神科医生在不了解实验室检查结果的情况下进行了诊断，并完成了评分量表。尽管所有催乳素水平都在正常范围内或接近正常水平，但我们发现精神分裂症亚型患者的催乳素血清水平存在显着差异：偏执型患者的最低值，精神分裂症患者的中间值最高，而杂乱无章的患者最高。结果似乎表明在偏执型精神分裂症中有明显的高多巴胺能活动，表明精神分裂症亚型之间的多巴胺能基调存在差异，并支持疾病亚型的临床和神经心理学个性。首发和复发患者之间精神分裂症亚型的催乳素血清水平无显着差异。似乎是急性精神病性非药物性精神分裂症患者，无论患者是首次入院还是复发，都具有恒定的多巴胺生物活性模式。

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