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首页> 外文期刊>Psychiatry research >The BDNF Val66Met polymorphism does not moderate the effect of self-reported physical activity on depressive symptoms in midlife
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The BDNF Val66Met polymorphism does not moderate the effect of self-reported physical activity on depressive symptoms in midlife

机译：BDNF Val66Met多态性不能缓解自我报告的体育锻炼对中年抑郁症状的影响

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摘要

The brain-derived neurotrophic factor (BDNF) Val66Met single nucleotide polymorphism may be associated with clinical and subsyndromal depression, but physical activity improves mood and increases BDNF expression. The aim of the study was to examine whether the BDNF polymorphism moderates an effect of physical activity on depressive symptoms. BDNF genotype. , physical activity measured by the Paffenbarger Questionnaire, and depressive symptoms using the Center for Epidemiology Depression Scale (CES-D) were collected on 1072 participants (mean age=44). Multiple linear regression was used to examine the association between BDNF genotype, physical activity, and depressive symptoms. After adjusting for family income, age, and education, depressive symptoms were higher in Met carriers compared to Val homozygotes (p=0.03), but this was only significant in men. Physical activity was associated with fewer depressive symptoms, but only in women (p=0.01). BDNF genotype did not moderate the effect of physical activity on depressive symptoms (p=0.94). In midlife, the BDNF Val66Met polymorphism neither attenuates nor magnifies the effect of physical activity on depressive symptoms.
机译：脑源性神经营养因子（BDNF）Val66Met单核苷酸多态性可能与临床和综合征下抑郁症相关，但体育锻炼可以改善情绪并增加BDNF的表达。这项研究的目的是检查BDNF多态性是否减轻了体育活动对抑郁症状的影响。 BDNF基因型。收集了1072名参与者（平均年龄= 44），通过《帕芬巴格问卷》测量的身体活动以及使用流行病学中心抑郁量表（CES-D）得出的抑郁症状。多元线性回归被用来检查BDNF基因型，体力活动和抑郁症状之间的关联。在调整了家庭收入，年龄和教育程度之后，与Val纯合子相比，Met携带者的抑郁症状更高（p = 0.03），但这仅在男性中显着。体力活动与较少的抑郁症状相关，但仅限于女性（p = 0.01）。 BDNF基因型不能缓解体育活动对抑郁症状的影响（p = 0.94）。在中年，BDNF Val66Met多态性既不会减弱也不会增强体育活动对抑郁症状的影响。

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