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首页> 外文期刊>Chemistry: A European journal >Porous iron oxide based nanorods developed as delivery nanocapsules
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Porous iron oxide based nanorods developed as delivery nanocapsules

机译：多孔氧化铁基纳米棒开发为递送纳米胶囊

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A low-temperature solution approach (90-95 degrees C) using FeCl3 and urea was carried out to synthesize beta-FeOOH nanorods in aqueous solution. The as-synthesized beta-FeOOH nanorods were further calcined at 300 degrees C to form porous nanorods with compositions including both beta-FeOOH and alpha-Fe2O3. The derived porous nanorods were engineered to assemble with four layers of polyelectrolytes (polyacrylic acid (PAA)/polyethylenimine(PEI)/PAA/ PEI) on their surfaces as polyelectrolyte multilayer nanocapsules. Fluorescein isothiocyanate (FITC) molecules were loaded into the polyelectrolyte multilayer nanocapsules in order to investigate drug release and intracellular delivery in Hela cells. The as-prepared nanocapsules showed ionic strength-dependent control of the permeability of the polyelectrolyte shells. The release behavior of the entrapped FITC from the FITC-loaded nanocapsules exhibited either controlled- or sustained-release trends, depending on the compactness of the polyelectrolyte shells on the nanorod surfaces. Cytotoxicity measurements demonstrate that the native nanorods and the polymercoated nanorods have excellent biocompatibility in all dosages between 0.1 ng mL(-1) and 100 mu gmL(-1). The time dependence of uptake of FITC-loaded nanocapsules by Hela cancer cells observed by laser confocal microscopy indicates that the nanocapsules can readily be taken up by cancer cells in 15 min, a relatively short period of time, while the slow release of the FITC from the initial perimembrane space into the cytoplasm was followed by release into the nucleus after 24 h.
机译：进行了使用FeCl3和尿素的低温溶液法（90-95摄氏度），以在水溶液中合成β-FeOOH纳米棒。将合成后的β-FeOOH纳米棒进一步在300摄氏度下煅烧，以形成具有包括β-FeOOH和α-Fe2O3的成分的多孔纳米棒。将衍生的多孔纳米棒设计为在其表面上与四层聚电解质（聚丙烯酸（PAA）/聚乙烯亚胺（PEI）/ PAA / PEI）组装在一起，作为聚电解质多层纳米胶囊。异硫氰酸荧光素（FITC）分子被装载到聚电解质多层纳米胶囊中，以研究Hela细胞中的药物释放和细胞内传递。所制备的纳米胶囊对聚电解质壳的渗透性表现出离子强度依赖性控制。从载有FITC的纳米胶囊中捕获的FITC的释放行为表现出控制释放或持续释放的趋势，具体取决于纳米棒表面上聚电解质壳的紧密度。细胞毒性测量表明，天然纳米棒和聚合物包被的纳米棒在0.1 ng mL（-1）至100μgmL（-1）之间的所有剂量下均具有出色的生物相容性。通过激光共聚焦显微镜观察到的Hela癌细胞摄取FITC纳米胶囊的时间依赖性表明，纳米胶囊很容易在15分钟内被癌细胞吸收，时间相对较短，而FITC的缓慢释放最初进入细胞质的膜周围空间，然后在24小时后释放到细胞核中。

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