Efficient H/D exchange reactions of alkyl-substituted benzene derivatives by means of the Pd/C-H-2-D2O system

Esaki H; Aoki F; Umemura M; Kato M; Maegawa T; Monguchi Y; Sajiki H

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Efficient H/D exchange reactions of alkyl-substituted benzene derivatives by means of the Pd/C-H-2-D2O system

机译：借助Pd / C-H-2-D2O系统进行烷基取代的苯衍生物的高效H / D交换反应

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A method for efficient and extensive H/D exchange of substituted benzene derivatives which is catalyzed by heterogeneous Pd/C in D2O as a deuterium source under hydrogen atmosphere is described. Multideuterium incorporation into unactivated linear or branched alkyl chains that bear a carboxyl, hydroxyl, ether, ester, or amide moiety and are connected with a benzene ring was achieved by using the Pd/C-H-2-D2O system. ne present method does not require expensive deuterium gas or any special equipment.

机译：描述了一种有效和广泛的H / D取代苯衍生物的H / D交换的方法，该方法是在氢气氛下，以D2O中的异质Pd / C作为氘源进行催化的。通过使用Pd / C-H-2-D2O系统，可以将多氘掺入未活化的带有羧基，羟基，醚，酯或酰胺部分并与苯环相连的直链或支链烷基链中。本方法不需要昂贵的氘气或任何专用设备。

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《Chemistry: A European journal》 |2007年第14期|共12页
作者
Esaki H; Aoki F; Umemura M; Kato M; Maegawa T; Monguchi Y; Sajiki H;
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正文语种 eng
中图分类化学;
关键词
C-H activation; deuterium; heterogeneous catalysis; isotopic labeling; palladium; HYDROGEN-DEUTERIUM EXCHANGE; H-D EXCHANGE; TRANSITION-METAL COMPLEXES; DILUTE ACID-MEDIUM; AROMATIC-COMPOUNDS; ISOTOPE-EXCHANGE; AMINO-ACIDS; HYDROTHERMAL CONDITION; ELEVATED-TEMPERATURES; SELECTIVE DEUTERATION;

机译：CH活化;氘;非均相催化;同位素标记;钯;氢-氘交换;HD交换;过渡金属络合物;稀酸-介质;芳族化合物;同位素交换;酰胺酸;温热条件选择性氘代;

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1. Efficient H/D exchange reactions of alkyl-substituted benzene derivatives by means of the Pd/C-H-2-D2O system [J] . Esaki H, Aoki F, Umemura M, Chemistry: A European journal . 2007,第14期

机译：借助Pd / C-H-2-D2O系统进行烷基取代的苯衍生物的高效H / D交换反应
2. Synthesis of the First C-2 Cyclopalladated Derivatives of l,3-Bis(2-pyridyl)benzene.Crystal Structures of [Hg(N-C-N)Cl],[Pd(N-C-N)Cl],and [Pd_2(N-C-N)_2(mu-OAc)]_2[Hg_2Cl_6].Catalytic Activity in the Heck Reaction [J] . Barbara Soro, Sergio Stoccoro, Giovanni Mkinghetti, Organometallics . 2005,第1期

机译：1,3-双（2-吡啶基）苯的第一个C-2环丙酸酯衍生物的合成。[Hg（NCN）Cl]，[Pd（NCN）Cl]和[Pd_2（NCN）_2（mu）的晶体结构-OAc）] _ 2 [Hg_2Cl_6] .Heck反应中的催化活性
3. X = Y-ZH systems as potential 1,3-dipoles. Part 61: Metal exchanged zeolites, silver(I) oxide, Ni(II) and Cu(I) complexes as catalysts for 1,3-dipolar cycloaddition reactions of imines generating proline derivatives [J] . Grigg R, Cooper DM, Holloway S, Tetrahedron . 2005,第36期

机译：X = Y-ZH系统作为潜在的1,3-偶极子。第61部分：金属交换的沸石，氧化银（I），Ni（II）和Cu（I）配合物作为亚胺生成脯氨酸衍生物的1,3-偶极环加成反应的催化剂
4. A Highly Efficient Implementation on GPU Clusters of PDE-Based Pricing Methods for Path-Dependent Foreign Exchange Interest Rate Derivatives [C] . Duy-Minh Dang, Christina C. Christara, Kenneth R. Jackson International conference on computational science and its applications . 2013

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5. The synthesis and reactivity of an alkyl-substituted derivative of m-xylylene: Benzene-1,3-diylbis(2-adamantyl) [D] . Currey, Jo Ann 1999

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6. An efficient Pd–NHC catalyst system in situ generated from Na2PdCl4 and PEG-functionalized imidazolium salts for Mizoroki–Heck reactions in water [O] . Nan Sun, Meng Chen, Liqun Jin, 2017

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7. Synthesis of the First C-2 Cyclopalladated Derivatives of 1, 3-Bis(2-pyridyl)benzene. Crystal Structures of Hg(N-C-N)Cl, Pd(N-C-N)Cl, and Pd2(N-C-N)2(m-OAc)2Hg2Cl6. Catalytic Activity in the Heck Reaction [O] . -1

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8. Phase Transfer Pd(O) Catalyzed Polymerization Reactions. 1. Synthesis of 1,2-(4,4'-Dialkoxyaryl)Acetylene Monomers and 1,4-Bis(2-(4',4''-Dialkoxyphenyl)Ethynyl)Benzene Derivatives by Phase Transfer Pd(O)/Cu(I) Catalyzed Coupling Reactions. [R] . Pugh, C., Percec, V. 1990

机译：相转移pd（O）催化的聚合反应。 1.相转移pd（O）/ Cu合成1,2-（4,4'-二烷氧基芳基）乙炔单体和1,4-双（2-（4'，4'-二烷氧基苯基）乙炔基）苯衍生物（I）催化的偶联反应。

Efficient H/D exchange reactions of alkyl-substituted benzene derivatives by means of the Pd/C-H-2-D2O system

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