Hydroaminomethylation with novel rhodium-carbene complexes: An efficient catalytic approach to pharmaceuticals

Ahmed M; Buch C; Routaboul L; Jackstell R; Klein H; Spannenberg A; Beller M

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Hydroaminomethylation with novel rhodium-carbene complexes: An efficient catalytic approach to pharmaceuticals

机译：新型铑-卡宾配合物的氢氨基甲基化：药物的有效催化方法

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Starting from [jRh(cod)Cl)21 and 1,3-dimesitylimidazole-2-ylidenes the novel [RhCl(cod)(carbene)] complexes 1-5 have been synthesized, characterized, and tested in the hydroaminomethylation of aromatic olefins. The influence of different ligands and reaction parameters on the catalytic activitywas investigated in detail applying 1,1diphenylethylene and piperidine as a model system. The scope and limitations of the novel catalysts is shown in the preparation of 16 biologically active 1-amino-3,3-diarylpropenes. In general, high chemo- and regioselectivity as well as good yields of the desired products were achieved.

机译：从[jRh（cod）Cl）21和1,3-二甲基咪唑-2-亚烷基开始，已经合成，表征和测试了新型[RhCl（cod）（carbene）]配合物1-5，并在芳族烯烃的氢氨基甲基化中进行了测试。以1，1－二苯基乙烯和哌啶为模型体系，详细研究了不同配体和反应参数对催化活性的影响。在制备16种具有生物活性的1-氨基-3,3-二芳基丙烯中显示了新型催化剂的范围和局限性。通常，获得了高的化学和区域选择性以及所需产物的良好产率。

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《Chemistry: A European journal》 |2007年第5期|共8页
作者
Ahmed M; Buch C; Routaboul L; Jackstell R; Klein H; Spannenberg A; Beller M;
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正文语种 eng
中图分类化学;
关键词
amines; carbenes; carbonylation; hydroaminomethylation; pharmaceuticals; rhodium; COUPLING REACTIONS; HYDROFORMYLATION; OLEFINS; HYDROGENATION; ARYLETHYLENES; SECONDARY; BEHAVIOR; STYRENE; SYSTEM; AMINES;

机译：胺;卡宾;羰基化;氢氨基甲基化;药物;铑;偶联反应;加氢甲酰化;烯烃;加氢;芳基乙烯;次级;行为;苯乙烯;体系;胺;

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1. Hydroaminomethylation with novel rhodium-carbene complexes: An efficient catalytic approach to pharmaceuticals [J] . Ahmed M, Buch C, Routaboul L, Chemistry: A European journal . 2007,第5期

机译：新型铑-卡宾配合物的氢氨基甲基化：药物的有效催化方法
2. Ni(Ⅰ)-X Complexes Bearing a Bulky α-Diimine Ligand: Synthesis, Structure, and Superior Catalytic Performance in the Hydrogen Isotope Exchange in Pharmaceuticals [J] . Zarate Cayetana, Yang Haifeng, Bezdek Mate J., Journal of the American Chemical Society . 2019,第12期

机译：带有庞大的α-二胺配体的Ni（Ⅰ）-X配合物：药物中氢同位素交换的合成，结构和优异的催化性能
3. Ni(Ⅰ)-X Complexes Bearing a Bulky α-Diimine Ligand: Synthesis, Structure, and Superior Catalytic Performance in the Hydrogen Isotope Exchange in Pharmaceuticals [J] . Zarate Cayetana, Yang Haifeng, Bezdek Mate J., Journal of the American Chemical Society . 2019,第12期

机译：含有庞大α-二亚胺配体的Ni（Ⅰ）-X复合物：药物中氢异形交换中的合成，结构和优异的催化性能
4. Catalytic Addition of Amines to Carbon Monoxide by Rare Earth Metal Complexes : An Efficient Synthesis of N-Substituted Formamides [C] . Toshiaki Suzuki, Zhaomin Hou Symposium on Organometallic Chemistry . 2008

机译：通过稀土金属配合物催化添加胺至一氧化碳：高效合成N-取代的甲酰胺
5. Ethylene-bis(indenyl) catalytic complexes: Efficient synthesis, introduction of the active metal species and immobilization. [D] . Panarello, Anthony P. 2005

机译：乙烯-双（茚基）催化络合物：高效合成，活性金属种类的引入和固定化。
6. Highly efficient degradation of pharmaceutical sludge by catalytic wet oxidation using CuO-CeO2/γ-Al2O3 as a catalyst [O] . Xu Zeng, Jun Liu, Jianfu Zhao 2012

机译：CuO-CeO2 /γ-Al2O3催化湿式氧化高效降解制药污泥
7. An Efficient Three-Component One-Pot Approach to the Synthesis of 2,3,4,5-Tetrahydro-1H-2-benzazepines by Means of Rhodium-Catalyzed Hydroaminomethylation [O] . -1

机译：通过铑催化的氢氨基甲基化合成2,3,4,5-四氢-1H-2-苯并嗪的合成的高效三组分一罐方法

Hydroaminomethylation with novel rhodium-carbene complexes: An efficient catalytic approach to pharmaceuticals

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