• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Psychiatry Research. Neuroimaging >White matter microstructural abnormalities in patients with late-onset schizophrenia identified by a voxel-based diffusion tensor imaging
【24h】

White matter microstructural abnormalities in patients with late-onset schizophrenia identified by a voxel-based diffusion tensor imaging

机译：通过基于体素的扩散张量成像确定的迟发性精神分裂症患者的白质微结构异常

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Reduced fractional anisotropy (FA) has been previously found in diffusion tensor imaging (DTI) studies of white matter in schizophrenic patients. However, there are no reports in the literature that address FA alterations in late-onset schizophrenia (LOS). The current study measured FA in whole white matter and subsequently analyzed its association with psychotic symptoms in LOS. DTI was carried out in 20 patients with LOS and 17 age-, gender- and education-matched healthy subjects. Fractional anisotropy in different areas of white matter was compared between groups using a voxelwise analysis after inter-subject registration to standard Montreal Neurological Institute (MNI) space. Psychotic symptoms were assessed using the Positive and Negative Syndrome Scale (PANSS). Cognitive functions were measured using the Wisconsin Card Sorting Test (WCST), the Digit Span Test, and the Trail-making Test. Significant reduction in FA was found in the left parietal lobe and right posterior cingulum in LOS patients compared with healthy subjects. Significant deficits in cognitive functions were observed in LOS. No significant correlation was found between FA value and PANSS scores, cognitive test scores, age, or antipsychotic medication dosages in LOS patients. Our study suggests that abnormalities in white matter integrity may contribute to the pathophysiology of LOS. However, these microstructural abnormalities provided no evidence for the emergence of psychotic symptoms in LOS.
机译：先前已经在精神分裂症患者的白质扩散张量成像（DTI）研究中发现了分数各向异性（FA）降低​​。然而，在文献中没有报告涉及晚期精神分裂症（LOS）中的FA改变。目前的研究测量了全白质中的FA，随后分析了其与LOS中精神病性症状的关系。在20例LOS患者和17例年龄，性别和教育程度相匹配的健康受试者中进行了DTI。在受试者间注册到标准蒙特利尔神经病学研究所（MNI）空间后，使用体素分析比较各组白质不同区域的分数各向异性。使用阳性和阴性综合征量表（PANSS）评估精神病症状。认知功能使用威斯康星卡片分类测试（WCST），数字跨度测试和追踪测试进行测量。与健康受试者相比，LOS患者的左顶叶和右后扣带中的FA显着降低。在LOS中观察到认知功能的明显缺陷。在LOS患者中，FA值与PANSS评分，认知测试评分，年龄或抗精神病药物剂量之间未发现显着相关性。我们的研究表明，白质完整性的异常可能与LOS的病理生理有关。但是，这些微结构异常并未为LOS中出现精神病症状提供证据。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号