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首页> 外文期刊>Psychiatry Research. Neuroimaging >An fMRI-study on semantic priming of panic-related information in depression without comorbid anxiety
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An fMRI-study on semantic priming of panic-related information in depression without comorbid anxiety

机译：功能性磁共振成像研究抑郁症中没有合并症的恐慌相关信息的语义启动

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摘要

Depression often involves anxiety symptoms and shows a strong comorbidity with panic disorder. However, the neural basis is unclear. The aim of the current study was to use semantic priming to investigate the neural correlates of panic and anxiety-related information processing in depression. In a lexical decision task, panic/agoraphobia-disorder-related and neutral word-pairs were presented during functional magnetic resonance imaging. Participants comprised 19 patients with major depression but without comorbid anxiety and 19 demographically matched controls. On a behavioral level, comparable significant priming effects were found for the neutral condition, while only patients showed a significant inhibition effect (slower reaction time for panic-related stimuli) for the panic condition. On a neural level, significant group differences emerged in left fronto-parietal (enhanced activation for patients) and left temporo-occipital regions (reduced activation for patients). The results showed that depressed patients recruit not only areas related to the interaction of emotion and semantic processing but also regions that are related to fear circuitry to process panic-related information. Hence, in the context of depression, there seems to be a pathological processing of panic-related information that could play an important role during the disorder and should be considered.
机译：抑郁症通常涉及焦虑症状，并表现为强烈的合并症和惊恐症。但是，神经基础尚不清楚。当前研究的目的是使用语义启动来研究抑郁症中与恐慌和焦虑相关的信息处理的神经相关性。在一项词汇决策任务中，在功能磁共振成像过程中出现了与恐慌/恐慌症相关的中性词对。参加者包括19名重度抑郁但无合并症焦虑症的患者和19位人口统计学匹配的对照组。在行为水平上，发现对于中性疾病具有可比的显着启动作用，而只有患者对恐慌疾病具有显着的抑制作用（对与恐慌相关的刺激的反应时间较慢）。在神经水平上，左额顶叶（增强患者的激活）和左颞枕区域（降低患者的激活）出现显着的组差异。结果表明，抑郁症患者不仅招募了与情感和语义处理的相互作用有关的区域，而且还招募了与处理恐惧相关信息的恐惧电路有关的区域。因此，在抑郁的情况下，似乎存在与恐慌有关的信息的病理学处理，该信息可能在疾病发作期间起重要作用，应予以考虑。

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