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Basal ganglia and thalamic morphology in schizophrenia and bipolar disorder

机译：精神分裂症和双相情感障碍的基底节和丘脑形态

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In this study, we examined the morphology of the basal ganglia and thalamus in bipolar disorder (BP), schizophrenia-spectrum disorders (SCZ-S), and healthy controls (HC) with particular interest in differences related to the absence or presence of psychosis. Volumetric and shape analyses of the basal ganglia and thalamus were performed in 33 BP individuals [12 without history of psychotic features (NPBP) and 21 with history of psychotic features (PBP)], 32 SCZ-S individuals [28 with SCZ and 4 with schizoaffective disorder], and 27 HC using FreeSurfer-initiated large deformation diffeomorphic metric mapping. Significant volume differences were found in the caudate and globus pallidus, with volumes smallest in the NPBP group. Shape abnormalities showing inward deformation of superior regions of the caudate were observed in BP (and especially in NPBP) compared with HC. Shape differences were also found in the globus pallidus and putamen when comparing BP and SCZ-S groups. No significant differences were seen in the nucleus accumbens and thalamus. In summary, structural abnormalities in the caudate and globus pallidus are present in BP and SCZ-S. Differences were more apparent in the NPBP subgroup. The findings herein highlight the potential importance of separately examining BP subgroups in neuroimaging studies.
机译：在这项研究中，我们检查了双相情感障碍（BP），精神分裂症-频谱障碍（SCZ-S）和健康对照（HC）的基底节和丘脑的形态，特别关注与精神病的有无相关的差异。对33名BP患者[12名无精神病史（NPBP）和21名有精神病史（PBP）]，32名SCZ-S患者[28名SCZ，4名SCZ]进行了基底节和丘脑的体积和形状分析。分裂情感障碍]和27 HC，使用FreeSurfer发起的大变形微分度量映射。在尾状和苍白球中发现明显的体积差异，在NPBP组中体积最小。与HC相比，在BP（尤其是NPBP）中观察到形状异常，显示尾状上半部向内变形。比较BP组和SCZ-S组时，在苍白球和壳状核中也发现了形状差异。在伏隔核和丘脑中未见明显差异。总之，在BP和SCZ-S中存在尾状和苍白球结构异常。在NPBP亚组中差异更加明显。本文的发现突出了在神经影像学研究中单独检查BP亚组的潜在重要性。

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