• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Psychiatry Research. Neuroimaging >Facilitation of emotion regulation with a single dose of escitalopram: A randomized fMRI study
【24h】

Facilitation of emotion regulation with a single dose of escitalopram: A randomized fMRI study

机译：单剂量艾司西酞普兰促进情绪调节：随机fMRI研究

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Acute antidepressant administration modulates neural activity consistent with decreases in negative emotion processing bias. However, studies are yet to examine whether treatment facilitates neural activity during reappraisal, an adaptive emotion regulation strategy associated with behavioral treatment response. Here we examine the impact of acute administration on reappraisal of negative stimuli using pharmaco-fMRI Thirty-six healthy female participants completed two sessions of fMRI scanning, separated by a one-week washout period. A single dose of the selective serotonin reuptake inhibitor, escitalopram (20 mg) was administered to participants using a double-blind, randomized, placebo-controlled crossover design. When participants were administered escitalopram (relative to a placebo) and asked to reappraise negative emotional stimuli, left amygdala activation was decreased and right inferior frontal gyms (R IFG) activation was increased. Also observed was a greater negative left amygdala-R IFG functional connectivity when participants were administered escitalopram relative to placebo, and this change in connectivity was associated with reductions in subjective ratings of valence and arousal of negative stimuli. Further analysis revealed connectivity modulation across multiple frontal regions. Results suggest that the acute effect of a commonly prescribed antidepressant may include facilitating the regulation of negative emotional stimuli, providing new important leads for models of antidepressant action. (C) 2015 Elsevier Ireland Ltd. All rights reserved.
机译：急性抗抑郁药的给药可调节神经活动，从而减少负性情绪处理偏差。然而，研究尚未检查治疗是否在重新评估期间促进神经活动，重新评估是与行为治疗反应相关的自适应情绪调节策略。在这里，我们使用Pharmacco-fMRI检查了急性给药对阴性刺激重新评估的影响。36名健康女性参与者完成了两次fMRI扫描，间隔了一个星期的冲洗期。使用双盲，随机，安慰剂对照的交叉设计将单剂量的选择性5-羟色胺再摄取抑制剂艾司西酞普兰（20 mg）给予受试者。当参与者服用依他普仑（相对于安慰剂）并要求重新评估负面情绪刺激时，左杏仁核的激活减少，右下额肌运动（R IFG）的激活增加。还观察到，参与者服用艾司西酞普兰相对于安慰剂时，左杏仁核-R IFG的功能性连接性更大，并且连接性的这种变化与主观价数的降低和对否定刺激的激发有关。进一步的分析揭示了跨多个额叶区域的连通性调制。结果表明，通常处方的抗抑郁药的急性作用可能包括促进负性情绪刺激的调节，为抗抑郁药的作用模型提供了新的重要线索。 （C）2015 Elsevier Ireland Ltd.保留所有权利。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号