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首页> 外文期刊>Psychiatry Research. Neuroimaging >Volumes of brain, grey and white matter and cerebrospinal fluid in schizophrenia in the Northern Finland 1966 Birth Cohort: An epidemiological approach to analysis
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Volumes of brain, grey and white matter and cerebrospinal fluid in schizophrenia in the Northern Finland 1966 Birth Cohort: An epidemiological approach to analysis

机译：芬兰北部精神分裂症的脑，灰质和白质以及脑脊液量1966年出生队列：一种流行病学分析方法

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Magnetic resonance imaging (MRI) studies in schizophrenia have seldom involved a general population birth cohort or other epidemiological samples. We studied the Northern Finland 1966 Birth Cohort and identified all people with psychotic disorders. Along with an unaffected age-matched control sample (n = 100) from the cohort, 54 subjects with schizophrenia underwent MRI brain scan at age 33-35 years from which we defined volumes of whole brain, grey and white matter and intracranial cerebrospinal fluid (CSF). Whole brain, grey and white matter volumes were 2-3% smaller in the schizophrenia subjects, who showed a 7% increase in CSF volume. These volume changes were independent of the effects of gender, family history of psychosis, perinatal risks or age at onset of illness. Moreover, there was no evidence that the effects were due to particular subgroups of cases having very low or high values. Rather, there were linear trends in the associations between whole brain and grey matter volume measures and schizophrenia. Our study replicates the previous findings of brain volume differences in schizophrenia on a general population level.
机译：精神分裂症的磁共振成像（MRI）研究很少涉及一般人群的出生队列或其他流行病学样本。我们研究了北芬兰1966年的出生队列，并确定了所有患有精神病的人。与队列中未受影响的年龄匹配对照样本（n = 100）一起，对54位精神分裂症患者在33-35岁时进行了MRI脑部扫描，从中我们定义了全脑，灰白质和颅内脑脊液的体积（ CSF）。精神分裂症患者的全脑，灰色和白色物质的体积减少了2-3％，脑脊液体积增加了7％。这些体积变化与性别，精神病家族史，围产期风险或发病年龄的影响无关。而且，没有证据表明这种影响是由于具有非常低或很高价值的特定病例分组所致。相反，全脑与灰质体积测量值与精神分裂症之间存在线性关系。我们的研究在一般人群水平上复制了精神分裂症中脑容量差异的先前发现。

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