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首页> 外文期刊>Psychiatry Research. Neuroimaging >Frontal cortical thinning and subcortical volume reductions in early adulthood obesity
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Frontal cortical thinning and subcortical volume reductions in early adulthood obesity

机译：成年早期肥胖者额叶皮质变薄和皮质下体积减少

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Obesity depends on homeostatic and hedonic food intake behavior, mediated by brain plasticity changes in cortical and subcortical structures. The aim of this study was to investigate cortical thickness and subcortical volumes of regions related to food intake behavior in a healthy young adult sample with obesity. Thirty-seven volunteers, 19 with obesity (age=33.7±5.7 (20-39) years body-mass index (BMI)=36.08±5.92 (30.10-49.69)kg/m2) and 18 controls (age=32.3±5.9 (21-40) years; BMI=22.54±1.94 (19.53-24.97)kg/m2) participated in the study. Patients with neuropsychiatric or biomedical disorders were excluded. We used FreeSurfer software to analyze structural magnetic resonance images (MRI) and obtain global brain measures, cortical thickness and subcortical volume estimations. Finally, correlation analyses were performed for brain structure data and obesity measures. There were no between-group differences in age, gender, intelligence or education. Results showed cortical thickness reductions in obesity in the left superior frontal and right medial orbitofrontal cortex. In addition, the obesity group had lower ventral diencephalon and brainstem volumes than controls, while there were no differences in any other subcortical structure. There were no statistically significant correlations between brain structure and obesity measures. Overall, our work provides evidence of the structural brain characteristics associated with metabolically normal obesity. We found reductions in cortical thickness, ventral diencephalon and brainstem volumes in areas that have been implicated in food intake behavior.
机译：肥胖症取决于大脑皮层和皮层下结构的可塑性变化所介导的体内稳态和享乐性食物的摄入行为。这项研究的目的是调查与健康的年轻成年人肥胖患者的食物摄入行为有关的区域的皮质厚度和皮质下体积。 37名志愿者，其中19名肥胖（年龄= 33.7±5.7（20-39）岁体重指数（BMI）= 36.08±5.92（30.10-49.69）kg / m2）和18名对照（年龄= 32.3±5.9（ 21-40岁）; BMI = 22.54±1.94（19.53-24.97）kg / m2）参与了研究。患有神经精神病或生物医学疾病的患者被排除在外。我们使用FreeSurfer软件分析结构磁共振图像（MRI）并获得整体脑部测量，皮质厚度和皮质下体积估计。最后，进行了脑结构数据和肥胖测量的相关分析。年龄，性别，智力或教育程度之间没有组间差异。结果显示，肥胖者左上额叶皮质和右内侧眶额叶皮质的皮质厚度减少。此外，肥胖组的腹侧中脑和脑干体积比对照组低，而其他皮质下结构无差异。大脑结构与肥胖测量之间无统计学意义的相关性。总体而言，我们的工作提供了与代谢正常肥胖相关的大脑结构特征的证据。我们发现与进食行为有关的区域皮质厚度，腹侧中脑和脑干体积减少。

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