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首页> 外文期刊>Psychiatry Research. Neuroimaging >Age-related cortical thickness differences in adolescents with early-onset schizophrenia compared with healthy adolescents
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Age-related cortical thickness differences in adolescents with early-onset schizophrenia compared with healthy adolescents

机译：与健康青少年相比，早发性精神分裂症青少年的年龄相关皮质厚度差异

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摘要

The aim of the present study was to investigate the influence of age on cerebral cortical thickness in adolescents with early-onset schizophrenia (EOS) (n=22, aged 12-18 years), as compared to an age-matched healthy control group (n=32). All participants were scanned with magnetic resonance imaging. Whereas in the healthy control group there was a negative association between increasing age and cortical thickness measures in widespread brain regions, including frontal and parietal cortices, the patient group showed no significant effects of age when the groups were studied separately. There was a trend towards an age-by-group effect in the left supramarginal gyrus and the right pre- and postcentral gyri. The between-group statistical analysis indicated similar cortical thickness in the patients as in the healthy controls. There were no significant effects of medication on cortical thickness, nor was there any significant sex-by-group interaction. The results suggest that patients with EOS have a deficiency of the expected cortical thinning to occur during adolescence development. The findings are discussed in context of neurobiological processes known to be involved in brain maturation, including synaptic reorganization, pruning and myelination.
机译：本研究的目的是与年龄匹配的健康对照组相比，研究年龄对患有早发性精神分裂症（EOS）（n = 22，年龄12-18岁）的青少年的大脑皮质厚度的影响（ n = 32）。所有参与者均进行了磁共振成像扫描。在健康对照组中，年龄增长与广泛的大脑区域（包括额叶和顶叶皮质）的皮质厚度测量值之间存在负相关关系，而单独研究各组时，患者组对年龄没有显着影响。左上颌上回和右前中后回都有按年龄增长的趋势。组间统计分析表明患者的皮质厚度与健康对照组相似。药物对皮层厚度没有显着影响，也没有显着的性别间相互作用。结果表明，EOS患者缺乏青春期发育过程中预期的皮质变薄现象。在已知与脑成熟有关的神经生物学过程的背景下讨论了这些发现，包括突触重组，修剪和髓鞘化。

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