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首页> 外文期刊>Psychiatry Research. Neuroimaging >Improved corpus callosum area measurements by analysis of adjoining parasagittal slices
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Improved corpus callosum area measurements by analysis of adjoining parasagittal slices

机译：通过分析相邻的矢状旁切面改善体面积测量

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摘要

The corpus callosum (CC) is a bundle of approximately 180 million axons connecting homologous areas of the left and right cerebral cortex. Because CC projections are topographically organized, regional CC morphological abnormalities may reflect regional cortical developmental abnormalities. We assess the variance characteristics of three CC area measurement techniques by comparing a single midsagittal slice versus three slices (midsagittal plus one parasagittal on each side) and five slices (midsagittal plus two parasagittal on each side). CC images were partitioned into five subregions using the Hofer-Frahm scheme under the three methods and variance was examined via two complementary data sets. In the first, to control for intersubject variability, 12 scans were acquired from a single subject over the course of 3. h. In the second, we used scans from 56 healthy male volunteers between the ages of 10 and 27 years (mean=17.47, S.D.=3.42). Increasing the number of slices from one to three to five diminished the coefficient of variation (CV) within subregions and increased the power to detect differences between groups. A power analysis was conducted for the sample under each method to determine the sample size necessary to discern a given percent change (delta) ranging from 1 to 20% iteratively.
机译：call体（CC）是一束大约1.8亿根轴突，连接左右大脑皮层的同源区域。由于CC投影是按地形组织的，因此区域CC形态异常可能反映了区域皮质发育异常。我们通过比较单个中矢状切面片与三个切面（中矢状切面加一个副矢状面，每侧）和五个切面（中矢状切面加两副矢状面，每侧）来评估三种CC面积测量技术的方差特征。在这三种方法下，使用Hofer-Frahm方案将CC图像划分为五个子区域，并通过两个互补数据集检查方差。首先，为了控制受试者之间的变异性，在3小时的过程中从单个受试者获得了12次扫描。在第二篇文章中，我们使用了来自56位年龄在10到27岁之间的健康男性志愿者的扫描（平均值为1.74，S.D。= 3.42）。将切片的数量从一增加到三到五将减少子区域内的变异系数（CV），并增加检测组之间差异的能力。对每种方法下的样品进行功效分析，以确定迭代辨别1至20％范围内给定百分比变化（delta）所需的样品量。

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