right hemispheric volume asymmetry, and reduced asymmetry in schizophrenia. Primary auditory cortex (A1) occupies the caudal-medial surface of HG'/> Hemispheric asymmetry of primary auditory cortex and Heschl's gyrus in schizophrenia and nonpsychiatric brains
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首页> 外文期刊>Psychiatry Research. Neuroimaging >Hemispheric asymmetry of primary auditory cortex and Heschl's gyrus in schizophrenia and nonpsychiatric brains
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Hemispheric asymmetry of primary auditory cortex and Heschl's gyrus in schizophrenia and nonpsychiatric brains

机译：精神分裂症和非精神病性大脑中主听皮层和赫氏回旋的半球不对称性

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摘要

Heschl's gyrus (HG) is reported to have a normal left>right hemispheric volume asymmetry, and reduced asymmetry in schizophrenia. Primary auditory cortex (A1) occupies the caudal-medial surface of HG, but it is unclear if A1 has normal asymmetry, or whether its asymmetry is altered in schizophrenia. To address these issues, we compared bilateral gray matter volumes of HG and A1, and neuron density and number in A1, in autopsy brains from male subjects with or without schizophrenia. Comparison of diagnostic groups did not reveal altered gray matter volumes, neuron density, neuron number or hemispheric asymmetries in schizophrenia. With respect to hemispheric differences, HG displayed a clear left>right asymmetry of gray matter volume. Area A1 occupied nearly half of HG, but had less consistent volume asymmetry, that was clearly present only in a subgroup of archival brains from elderly subjects. Neuron counts, in layers IIIb-c and V-VI, showed that the A1 volume asymmetry reflected differences in neuron number, and was not caused simply by changes in neuron density. Our findings confirm previous reports of striking hemispheric asymmetry of HG, and additionally show evidence that A1 has a corresponding asymmetry, although less consistent than that of HG.
机译：据报道，赫氏回旋（HG）具有正常的左>右半球体积不对称性，并减少了精神分裂症的不对称性。初级听觉皮层（A1）占据HG的尾内侧表面，但是尚不清楚A1是否具有正常的不对称性，或者在精神分裂症中其不对称性是否改变。为了解决这些问题，我们比较了患有或未患有精神分裂症的男性受试者的尸检大脑中HG和A1的双边灰质体积以及A1中的神经元密度和数量。诊断组的比较未显示精神分裂症的灰质体积，神经元密度，神经元数量或半球不对称性改变。关于半球差异，HG显示出灰质体积明显的左右不对称性。区域A1占据了近一半的HG，但体积不对称性较小，这显然只存在于老年受试者的档案大脑亚组中。在IIIb-c和V-VI层中的神经元计数表明，A1体积不对称反映了神经元数量的差异，而不仅仅是由神经元密度的变化引起的。我们的发现证实了以前关于HG的半球不对称性的报道，此外还显示了A1具有相应的不对称性的证据，尽管不如HG一致。

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