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首页> 外文期刊>Psychiatry Research. Neuroimaging >Abnormal white matter integrity and decision-making deficits in alcohol dependence
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Abnormal white matter integrity and decision-making deficits in alcohol dependence

机译：白质完整性异常和酒精依赖的决策缺陷

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To date, there is no study that explored the correlation of microstructural changes in the whole brain white matter (WM) and decision-making in alcohol dependent patients (ADP). In the present study, we applied Tract Based Spatial Statistics (TBSS) to study WM changes in ADP compared with healthy controls. We also tested whether there was any relationship between WM integrity and decision-making in ADP. The study included 17 inpatient ADP who had been abstinent for at least 2 weeks before testing and scanning and 16 healthy control subjects. The Iowa Gambling Task (IGT) was used to measure decision-making. Results for the IGT showed a significant group (ADP vs. control) by block interaction. Follow-up univariate analyses of variance showed that the groups were significantly different in the last 20 trails. Four significant clusters were found in which fractional anisotropy was significantly lower in ADP than in control subjects, including the corpus callosum and parietal, occipital and frontal regions. We found significant correlations between impaired IGT performance in the last 20 trials and WM integrity in these regions. Together, these results might help to explain observed decision making deficits in ADP.
机译：迄今为止，尚无研究探讨全脑白质（WM）的微观结构变化与酒精依赖患者（ADP）决策的相关性。在本研究中，我们应用基于行迹的空间统计（TBSS）研究ADP中WM与健康对照相比的变化。我们还测试了WM完整性与ADP中的决策之间是否存在任何关系。该研究包括17名住院ADP患者和16名健康对照患者，ADP患者在测试和扫描前禁食至少2周。爱荷华州赌博任务（IGT）用于衡量决策。通过块相互作用，IGT的结果显示了一个重要的组（ADP与对照组）。后续的单变量方差分析表明，在最近的20条试验中，各组之间存在显着差异。发现了四个重要的簇，其中ADP的分数各向异性显着低于对照组，包括call体和顶叶，枕叶和额叶区域。我们发现最近20项试验中受损的IGT性能与这些地区的WM完整性之间存在显着相关性。总之，这些结果可能有助于解释ADP中观察到的决策缺陷。

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