• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Psychiatry Research. Neuroimaging >Pharmaco-MEG evidence for attention related hyper-connectivity between auditory and prefrontal cortices in ADHD
【24h】

Pharmaco-MEG evidence for attention related hyper-connectivity between auditory and prefrontal cortices in ADHD

机译：注意力相关的多动症听觉和前额叶皮质之间的超连通性的Pharmaco-MEG证据

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

The ability to attend to particular stimuli while ignoring others is crucial in goal-directed activities and has been linked with prefrontal cortical regions, including the dorsolateral prefrontal cortex (DLPFC). Both hyper- and hypo-activation in the DLPFC has been reported in patients with attention-deficit/hyperactivity disorder (ADHD) during many different cognitive tasks, but the network-level effects of such aberrant activity remain largely unknown. Using magnetoencephalography (MEG), we examined functional connectivity between regions of the DLPFC and the modality-specific auditory cortices during an auditory attention task in medicated and un-medicated adults with ADHD, and those without ADHD. Participants completed an attention task in two separate sessions (medicated/un-medicated), and each session consisted of two blocks (attend and no-attend). All MEG data were coregistered to structural MRI, corrected for head motion, and projected into source space. Subsequently, we computed the phase coherence (i.e., functional connectivity) between DLPFC regions and the auditory cortices. We found that un-medicated adults with ADHD exhibited greater phase coherence in the beta (14-30. Hz) and gamma frequency (30-56. Hz) range in attend and no-attend conditions compared to controls. Stimulant medication attenuated these differences, but did not fully eliminate them. These results suggest that aberrant bottom-up processing may engulf executive resources in ADHD.
机译：在针对目标的活动中，参与特定刺激而忽略其他刺激的能力至关重要，并且已与包括额外侧前额叶皮质（DLPFC）在内的前额叶皮质区域相关联。在许多不同的认知任务中，患有注意力缺陷/多动障碍（ADHD）的患者都报道了DLPFC的过度激活和过度激活，但这种异常活动的网络水平影响仍然未知。我们使用磁脑描记法（MEG），在患有ADHD和未患有ADHD的药物和非药物成人中，在听觉注意任务中检查了DLPFC区域与特定于模式的听觉皮层之间的功能连接性。参加者在两个单独的环节（有药物/无药物）中完成了一项关注任务，并且每个环节都由两个部分组成（参加和不参加）。将所有MEG数据共同注册到结构MRI，校正头部运动，然后投射到源空间中。随后，我们计算了DLPFC区域与听觉皮层之间的相位相干性（即功能连接性）。我们发现，与对照组相比，患有ADHD的未经药物治疗的成年人在出勤和无人看管条件下的β（14-30。Hz）和伽马频率（30-56。Hz）范围内表现出更大的相位相干性。刺激性药物减弱了这些差异，但并未完全消除它们。这些结果表明，异常的自下而上的处理可能会吞噬ADHD中的执行资源。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号