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Effect of altitude on brain intracellular pH and inorganic phosphate levels

机译：海拔高度对大脑细胞内pH和无机磷酸盐水平的影响

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摘要

Normal brain activity is associated with task-related pH changes. Although central nervous system syndromes associated with significant acidosis and alkalosis are well understood, the effects of less dramatic and chronic changes in brain pH are uncertain. One environmental factor known to alter brain pH is the extreme, acute change in altitude encountered by mountaineers. However, the effect of long-term exposure to moderate altitude has not been studied. The aim of this two-site study was to measure brain intracellular pH and phosphate-bearing metabolite levels at two altitudes in healthy volunteers, using phosphorus-31 magnetic resonance spectroscopy (31P-MRS). Increased brain pH and reduced inorganic phosphate (Pi) levels were found in healthy subjects who were long-term residents of Salt Lake City, UT (4720ft/1438m), compared with residents of Belmont, MA (20ft/6m). Brain intracellular pH at the altitude of 4720ft was more alkaline than that observed near sea level. In addition, the ratio of inorganic phosphate to total phosphate signal also shifted toward lower values in the Salt Lake City region compared with the Belmont area. These results suggest that long-term residence at moderate altitude is associated with brain chemical changes.
机译：正常的大脑活动与任务相关的pH值变化有关。尽管与严重酸中毒和碱中毒有关的中枢神经系统综合征已广为人知，但不确定大脑pH的剧烈变化和慢性变化的影响。已知会改变大脑pH值的一种环境因素是登山者遇到的海拔高度的急剧变化。但是，尚未研究长期暴露于中等高度的影响。这项为期两点的研究的目的是使用磷31磁共振波谱（31P-MRS）在健康志愿者中的两个高度测量大脑细胞内pH值和带有磷酸盐的代谢物水平。与马萨诸塞州贝尔蒙特市居民（20ft / 6m）相比，健康受试者的大脑pH值升高，无机磷酸盐（Pi）水平降低，他们是犹他州盐湖城的长期居民（4720ft / 1438m）。在海拔4720英尺处，大脑细胞内pH值比在海平面附近观察到的碱性更高。此外，与贝尔蒙特地区相比，盐湖城地区的无机磷酸盐与总磷酸盐信号之比也向较低的方向偏移。这些结果表明，在中等高度的长期居住与大脑化学变化有关。

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