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首页> 外文期刊>Psychiatry Research. Neuroimaging >Impairments of event-related magnetic fields in schizophrenia patients with predominant negative symptoms
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Impairments of event-related magnetic fields in schizophrenia patients with predominant negative symptoms

机译：具有主要阴性症状的精神分裂症患者的事件相关磁场损害

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Recently there is a growing understanding that patients suffering from negative symptoms of schizophrenia represent a distinct patient population. However, despite the abundance of EEG studies characterizing schizophrenia patients in general, only a handful of studies have focused on the electrophysiological correlates of negative symptoms. The current study examined whether the impairments in event-related magnetic fields (ERFs) commonly reported in heterogeneous groups of patients with mixed positive and negative symptoms also occur in patients with predominantly negative symptoms, and investigated their correlation to clinical symptoms and cognitive deficits. Twenty schizophrenia patients suffering from predominant negative symptoms and 25 healthy subjects underwent neuropsychological and electromagnetic assessments. ERB were recorded during a three-stimuli novelty oddball and a sensory gating paradigm, and M50. P300m and Novelty-P3m components were investigated. Patients displayed impaired M50 ratios, reduced left P300m and frontal Novelty-P3m amplitudes. These electromagnetic measures correlated significantly with the severity of negative symptoms (SANS scale). The electrophysiological abnormalities which have been proposed as candidate biomarkers for schizophrenia are also manifested in patients with predominantly negative symptoms. (C) 2015 Elsevier Ireland Ltd. All rights reserved.
机译：最近，人们越来越多地了解到，患有精神分裂症阴性症状的患者代表着不同的患者群体。然而，尽管一般来说精神分裂症患者有大量的脑电图研究，但只有少数研究集中于阴性症状的电生理相关性。本研究检查了异种阳性和阴性症状混合患者中通常报告的事件相关磁场（ERF）损伤是否也出现在主要为阴性症状的患者中，并研究了它们与临床症状和认知缺陷的相关性。 20例主要表现为阴性症状的精神分裂症患者和25名健康受试者接受了神经心理学和电磁学评估。在三刺激性奇异球和感觉门控范例中记录了ERB，以及M50。研究了P300m和Novelty-P3m组件。患者表现出M50比率受损，左P300m降低和额部Novelty-P3m振幅降低。这些电磁测量与阴性症状的严重程度（SANS评分）显着相关。已经被提议作为精神分裂症候选生物标志物的电生理异常也出现在主要为阴性症状的患者中。 （C）2015 Elsevier Ireland Ltd.保留所有权利。

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