• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Psychiatry Research. Neuroimaging >Medial frontal gyrus alterations in schizophrenia: Relationship with duration of illness and executive dysfunction
【24h】

Medial frontal gyrus alterations in schizophrenia: Relationship with duration of illness and executive dysfunction

机译：精神分裂症的内侧额回回改变：与疾病持续时间和执行功能障碍的关系

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Executive functioning is consistently impaired in schizophrenia, and it has been associated with reduced gray matter volume in prefrontal areas. Abnormalities in prefrontal brain regions have also been related to the illness duration. The aim of the study was to investigate the effect of executive functioning decline and chronicity in prefrontal regions of patients with schizophrenia. Participants comprised 33 schizophrenic patients, 18 with duration of illness (Dol) shorter than 10 years and 15 with duration of illness longer than 10 years. In addition, 24 healthy controls served as a comparison group. Participants performed the Wisconsin Card Sorting Test (WCST) and underwent structural magnetic resonance imaging. Patients with longer Dol showed significant reduction of gray matter volume in the left medial frontal gyms compared with healthy controls. Moreover, there was a trend for greater gray matter volume decrease in patients with a longer illness duration compared with patients with shorter illness duration. There was no interaction between the volume of the left medial frontal gyms performance on the WCST. The present study supports the hypothesis that medial frontal gyrus alterations in schizophrenia are sensitive to duration of illness. These alterations were not associated with executive functioning. (C) 2014 Elsevier Ireland Ltd. All rights reserved,
机译：在精神分裂症中，执行功能一直受到损害，并且与前额叶区域灰质体积的减少有关。前额脑区域的异常也与疾病持续时间有关。这项研究的目的是调查精神分裂症患者前额叶区域执行功能下降和慢性的影响。参与者包括33位精神分裂症患者，18位病程（Dol）少于10年的患者和15位病程超过10年的患者。另外，将24名健康对照组作为比较组。参与者进行了威斯康星卡片分类测试（WCST），并进行了结构磁共振成像。 Dol较长的患者与健康对照组相比，左内侧额叶体育馆的灰质体积明显减少。而且，与疾病持续时间较短的患者相比，疾病持续时间较长的患者有减少灰质体积的趋势。 WCST上左内侧额叶体育馆的表演量之间没有相互作用。本研究支持以下假设：精神分裂症的内侧额叶回变化对疾病的持续时间敏感。这些变化与执行功能无关。 （C）2014 Elsevier Ireland Ltd.保留所有权利，

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号