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首页> 外文期刊>Psychiatry Research. Neuroimaging >White matter volume abnormalities and associations with symptomatology in schizophrenia
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White matter volume abnormalities and associations with symptomatology in schizophrenia

机译：精神分裂症患者白质容量异常及其与症状的关系

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The cerebral white matter (WM) is critically involved in many bio-behavioral functions impaired in schizophrenia. However, the specific neural systems underlying symptomatology in schizophrenia are not well known. By comparing the volume of all brain fiber systems between chronic patients with DSM-III-R schizophrenia (n = 88) and matched healthy community controls (n = 40), we found that a set of a priori WM regions of local and distal associative fiber systems was significantly different in patients with schizophrenia. There were significant positive correlations between volumes (larger) in anterior callosal, cingulate and temporal deep WM regions (related to distal connections) with positive symptoms, such as hallucinations, delusions and bizarre behavior, and significant negative correlation between volumes (smaller) in occipital and paralimbic superficial WM (related to local connections) and posterior callosal fiber systems with higher negative symptoms, such as alogia. Furthermore, the temporal sagittal system showed significant rightward asymmetry between patients and controls. These observations suggest a pattern of volume WM alterations associated with symptomatology in schizophrenia that may be related in part to predisposition to schizophrenia.
机译：脑白质（WM）关键参与精神分裂症受损的许多生物行为功能。但是，精神分裂症症状的基础特定神经系统尚不清楚。通过比较DSM-III-R精神分裂症慢性患者（n = 88）和相匹配的健康社区对照（n = 40）之间所有脑纤维系统的体积，我们发现了一组局部和远侧相关的先验WM区精神分裂症患者的纤维系统明显不同。前call，扣带回和颞深WM区（与远端连接有关）的容积（较大）与幻觉，妄想和怪异行为等积极症状之间存在显着正相关，枕骨容积（较小）之间（较小）之间存在显着的负相关。以及半肢上浅表性WM（与局部连接有关）和后方os骨纤维系统具有较高的阴性症状，例如失语。此外，颞矢状系统在患者和对照之间显示出明显的向右不对称性。这些观察结果表明与精神分裂症症状相关的大量WM改变模式可能与精神分裂症的易感性有关。

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