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首页> 外文期刊>Psychiatry Research. Neuroimaging >Abnormal striatal resting-state functional connectivity in adolescents with obsessive-compulsive disorder
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Abnormal striatal resting-state functional connectivity in adolescents with obsessive-compulsive disorder

机译：强迫症青少年的纹状体静息状态功能连接异常

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Neuroimaging research has implicated abnormalities in cortico-striatal-thalamic-cortical (CSTC) circuitry in pediatric obsessive-compulsive disorder (OCD). In this study, resting-state functional magnetic resonance imaging (R-fMRI) was used to investigate functional connectivity in the CSTC circuitry in adolescents with OCD. Imaging was obtained with the Human Connectome Project (HCP) scanner using newly developed pulse sequences which allow for higher spatial and temporal resolution. Fifteen adolescents with OCD and 13 age- and gender-matched healthy controls (ages 12-19) underwent R-fMRI on the 3T HCP scanner. Twenty-four minutes of resting-state scans (two consecutive 12-min scans) were acquired. We investigated functional connectivity of the striatum using a seed-based, whole brain approach with anatomically-defined seeds placed in the bilateral caudate, putamen, and nucleus accumbens. Adolescents with OCD compared with controls exhibited significantly lower functional connectivity between the left putamen and a single cluster of right-sided cortical areas including parts of the orbitofrontal cortex, inferior frontal gyms, insula, and operculum. Preliminary findings suggest that impaired striatal connectivity in adolescents with OCD in part falls within the predicted CSTC network, and also involves impaired connections between a key CSTC network region (i.e., putamen) and key regions in the salience network (i.e., insula/operculum). The relevance of impaired putamen-insula/operculum connectivity in OCD is discussed. (C) 2015 Elsevier Ireland Ltd. All rights reserved.
机译：神经影像学研究提示小儿强迫症（OCD）的皮质-纹状体-丘脑-皮质（CSTC）电路异常。在这项研究中，静息状态功能磁共振成像（R-fMRI）用于研究患有OCD的青少年CSTC电路中的功能连接性。成像是使用新开发的脉冲序列通过人类连接基因组计划（HCP）扫描仪获得的，可以提供更高的时空分辨率。在3T HCP扫描仪上对15名患有强迫症的青少年和13名年龄和性别相匹配的健康对照（12-19岁）进行了R-fMRI。获得二十四分钟的静息状态扫描（两次连续的12分钟扫描）。我们使用基于种子的全脑方法，将解剖学定义的种子置于双侧尾状，壳壳和伏隔核中，调查了纹状体的功能连接性。与对照组相比，患有强迫症的青少年表现出左侧核壳蛋白和右侧皮质区域（包括额额叶皮质，下额额体育馆，岛下和盖）的单个簇之间的功能连通性明显降低。初步发现表明，OCD青少年的纹状体连通性受损部分属于预期的CSTC网络，并且还涉及关键CSTC网络区域（即壳核）和显着网络中的关键区域（即，岛/ oper骨）之间的连接受损。 。讨论了OCD中受损的壳核/腹膜连通性的相关性。 （C）2015 Elsevier Ireland Ltd.保留所有权利。

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