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首页> 外文期刊>Psychiatry Research. Neuroimaging >Bilateral functional asymmetry disparity in positive and negative schizophrenia revealed by resting-state
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Bilateral functional asymmetry disparity in positive and negative schizophrenia revealed by resting-state

机译：静息状态显示精神分裂症阳性和阴性的双边功能不对称差异

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摘要

Brain functional asymmetry abnormalities have previously been reported in schizophrenia. In the present study, we hypothesized that the pattern of functional asymmetry in schizophrenia may differ between patients suffering from positive and negative symptoms. We examined the relationship between altered asymmetry of functional connectivity and symptom type (positiveegative) using resting-state functional magnetic resonance imaging. We selected the dorsolateral prefrontal cortex, superior temporal gyms, middle temporal gyrus and hippocampus as regions of interest, and analyzed functional connectivity patterns between these and other brain regions. Furthermore, a voxel-based two-level asymmetry analysis was conducted to investigate differences in the asymmetry of functional connectivity patterns within and between groups. Our results showed that patients exhibiting positive symptoms had significantly increased leftward asymmetry of functional connectivity. The negative symptom group, in contrast, exhibited increased rightward asymmetry of functional connectivity. The strength of the asymmetry in these regions was found to be significantly correlated with symptom ratings obtained using the Positive and Negative Syndrome Scale. These results suggest that predominantly positive and predominantly negative schizophrenia may have different neural underpinnings, and that certain regions in the frontal and temporal lobes, as well as the cingulate gyrus and precuneus, play important roles in mediating the symptoms of this complex disease. Our study also provided further evidence for the hypothesis that schizophrenia is related to abnormalities in functional brain networks.
机译：先前已在精神分裂症中报道过脑功能不对称异常。在本研究中，我们假设精神分裂症患者的功能不对称模式在患有阳性和阴性症状的患者之间可能有所不同。我们使用静止状态功能磁共振成像检查功能连接的不对称性改变和症状类型（正/负）之间的关系。我们选择了背外侧前额叶皮层，颞上体育馆，颞中回和海马作为感兴趣的区域，并分析了这些区域与其他大脑区域之间的功能连接方式。此外，进行了基于体素的两级不对称性分析，以研究组内和组间功能连接模式的不对称性差异。我们的结果表明，表现出阳性症状的患者功能连接的左向不对称性明显增加。相反，阴性症状组表现出功能连接的向右不对称性增加。发现在这些区域中的不对称强度与使用阳性和阴性综合征量表获得的症状等级显着相关。这些结果表明，主要为阳性和主要为阴性的精神分裂症可能具有不同的神经基础，额叶和颞叶的某些区域以及扣带回和前突神经在介导此复杂疾病的症状中起重要作用。我们的研究还为精神分裂症与功能性大脑网络异常有关的假说提供了进一步的证据。

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