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首页> 外文期刊>Psychiatry Research. Neuroimaging >MRI correlates of episodic memory in Alzheimer's disease, mild cognitive impairment, and healthy aging.
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MRI correlates of episodic memory in Alzheimer's disease, mild cognitive impairment, and healthy aging.

机译：MRI与阿尔茨海默氏病，轻度认知障碍和健康衰老中的情景记忆有关。

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Episodic memory is a core feature of Alzheimer's disease (AD) and mild cognitive impairment (MCI). Impaired episodic memory in AD results from the dysfunction of an integrated network and involves both gray and white matter pathologies. We explored the neural correlates of episodic memory in AD, MCI and healthy aging by correlating a measure of episodic memory with hippocampal volume and fractional anisotropy (FA) and mean diffusivity (MD) of the cingulum and fornix. Episodic memory was associated with hippocampal volume and MD of the cingulum and fornix. In contrast, there were fewer significant associations between episodic memory and FA. These findings support a relationship between episodic memory and hippocampal circuitry, and suggest that MD is a more sensitive marker of decreased white matter integrity in the study of AD and MCI than FA. Furthermore, MD was significantly associated with hippocampal volume, indicating that white matter pathology is not completely independent of gray matter pathology. However, the pattern of diffusivity differences in AD and MCI implies a more complex pathology than simply Wallerian degeneration.
机译：情景记忆是阿尔茨海默氏病（AD）和轻度认知障碍（MCI）的核心特征。 AD中的情景记忆受损是由集成网络的功能障碍导致的，涉及灰质和白质病理。我们通过将发作性记忆的量度与海马体积和扣带和穹ni的分数各向异性（FA）以及平均扩散率（MD）相关联，探索了AD，MCI和健康衰老中的发作性记忆的神经相关性。发作性记忆与海马体积以及扣带和穹MD的MD有关。相反，情节记忆与FA之间的重要关联较少。这些发现支持了发作性记忆与海马回路之间的关系，并且表明在AD和MCI的研究中，MD是白质完整性降低的更敏感标志物，而不是FA。此外，MD与海马体积显着相关，表明白质病理并非完全独立于灰质病理。但是，AD和MCI的扩散率差异模式意味着比简单的Wallerian变性更为复杂的病理。

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