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首页> 外文期刊>Psychiatry Research. Neuroimaging >Double-blind randomized trial of risperidone versus divalproex in pediatric bipolar disorder: fMRI outcomes.
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Double-blind randomized trial of risperidone versus divalproex in pediatric bipolar disorder: fMRI outcomes.

机译：利培酮与divalproex在小儿双相情感障碍中的双盲随机试验：fMRI结果。

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The aim of this research was to determine the relative effects of risperidone and divalproex on brain function in pediatric mania. This is a double-blind 6-week functional magnetic resonance imaging trial with 24 unmedicated manic patients randomized to risperidone or divalproex, and 14 healthy controls (HCs) matched for IQ and demographic factors (mean age: 13.1+/-3.3years). A pediatric affective color matching task, in which subjects matched the color of a positive, negative or neutral word with one of two colored circles, was administered. The primary clinical measure was the Young Mania Rating Scale (YMRS). The risperidone group, relative to HC, showed an increase in activation from pre- to post-treatment in right pregenual and subgenual anterior cingulate cortex and decreased activation in bilateral middle frontal gyrus during the negative condition; and decreased activation in left inferior and medial, and right middle frontal gyri, left inferior parietal lobe, and right striatum with positive condition. In the divalproex group, relative to HC, there was an increased activation in right superior temporal gyrus in the negative condition; and in left medial frontal gyrus and right precuneus with the positive condition. Greater pre-treatment right amygdala activity with negative and positive condition in the risperidone group, and left amygdala activity with positive condition in divalproex group, predicted poor response on YMRS. Risperidone and divalproex yield differential patterns of prefrontal activity during an emotion processing task in pediatric mania. Increased amygdala activity at baseline is a potential biomarker predicting poor treatment response to both the risperidone and divalproex.
机译：这项研究的目的是确定利培酮和双丙戊酸钠对小儿躁狂症脑功能的相对影响。这是一项为期6周的双盲功能磁共振成像试验，其中24例随机分配给利培酮或divalproex的躁狂躁狂患者和14例智商和人口统计学因素匹配的健康对照（HCs）（平均年龄：13.1 +/- 3.3岁）。进行了儿科情感色彩匹配任务，其中受试者将正，负或中性词的颜色与两个彩色圆圈之一匹配。主要的临床指标是年轻躁狂症评定量表（YMRS）。相对于HC，利培酮组在治疗前和治疗后右前扣带回皮层的激活增加，而在阴性条件下双侧中额回的激活减少。呈阳性状态的左下，中，右额中回，右下顶叶和右纹状体的激活降低。相对于HC，在divalproex组中，阴性条件下右上颞回的激活增加。阳性时左内侧额回和右前突。利培酮组在治疗前的杏仁核活性较高，阴性和阳性，而在双丙戊酸组中，杏仁核的阳性活性较高，预示对YMRS的反应较差。在小儿躁狂症的情绪处理任务期间，利培酮和双丙戊酸钠可产生前额叶活动的不同模式。基线时杏仁核活性的增加是潜在的生物标志物，预示着对利培酮和divalproex的不良治疗反应。

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