• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Psychiatry Research. Neuroimaging >Resting state cerebral blood flow and objective motor activity reveal basal ganglia dysfunction in schizophrenia.
【24h】

Resting state cerebral blood flow and objective motor activity reveal basal ganglia dysfunction in schizophrenia.

机译：静止状态的脑血流量和客观运动活动揭示了精神分裂症的基底神经节功能障碍。

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Reduced motor activity has been reported in schizophrenia and was associated with subtype, psychopathology and medication. Still, little is known about the neurobiology of motor retardation. To identify neural correlates of motor activity, resting state cerebral blood flow (CBF) was correlated with objective motor activity of the same day. Participants comprised 11 schizophrenia patients and 14 controls who underwent magnetic resonance imaging with arterial spin labeling and wrist actigraphy. Patients had reduced activity levels and reduced perfusion of the left parahippocampal gyrus, left middle temporal gyrus, right thalamus, and right prefrontal cortex. In controls, but not in schizophrenia, CBF was correlated with activity in the right thalamic ventral anterior (VA) nucleus, a key module within basal ganglia-cortical motor circuits. In contrast, only in schizophrenia patients positive correlations of CBF and motor activity were found in bilateral prefrontal areas and in the right rostral cingulate motor area (rCMA). Grey matter volume correlated with motor activity only in the left posterior cingulate cortex of the patients. The findings suggest that basal ganglia motor control is impaired in schizophrenia. In addition, CBF of cortical areas critical for motor control was associated with volitional motor behavior, which may be a compensatory mechanism for basal ganglia dysfunction.
机译：据报道精神分裂症患者的运动能力降低，并与亚型，精神病理学和药物治疗相关。但是，关于运动迟缓的神经生物学知之甚少。为了确定运动活动的神经相关性，将静息状态的脑血流量（CBF）与当天的客观运动活动相关联。参加者包括11位精神分裂症患者和14位对照者，他们接受了带有动脉自旋标记和腕部活动描记术的磁共振成像。患者的活动水平降低，左海马旁回，左中颞回，右丘脑和右前额叶皮层的灌注减少。在对照而非精神分裂症中，CBF与右丘脑腹前核（VA）核的活动相关，VA是基底神经节-皮质运动回路中的关键模块。相反，仅在精神分裂症患者中，在双侧前额叶区域和右延髓扣带运动区（rCMA）中发现CBF与运动活动呈正相关。灰质体积仅与患者左后扣带回皮层的运动活动相关。这些发现表明精神分裂症患者的基底节运动控制受损。此外，对于运动控制至关重要的皮质区域的CBF与自主运动行为有关，这可能是基底神经节功能障碍的一种补偿机制。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号