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首页> 外文期刊>Psychiatry Research. Neuroimaging >A comparative evaluation of quantitative neuroimaging measurements of brain status in HIV infection
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A comparative evaluation of quantitative neuroimaging measurements of brain status in HIV infection

机译：艾滋病毒感染者大脑状态的定量神经影像学测量的比较评估

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摘要

Diffusion tensor imaging (DTI), magnetization transfer imaging (MT) and automated brain volumetry were used to summarize brain involvement in human immunodeficiency virus (HIV) infection. A multiparametric neuroimaging protocol was implemented at 1.5. T in 10 HIV. + and 24 controls. Various summary parameters were calculated based on DTI, MT, and automated brain volumetry. The magnitude of the difference, as well as the between-group discrimination, was determined for each measure. Bivariate correlations were computed and redundancy among imaging parameters was examined by principal factor analysis. Significant or nearly significant differences were found for most measures. Large Cohen's d effect sizes were indicated for mean diffusivity (MD), fractional anisotropy (FA), magnetization transfer ratio (MTR) and gray matter volume fraction (GM). Between-group discrimination was excellent for FA and MTR and acceptable for MD. Correlations among all imaging parameters could be explained by three factors, possibly reflecting general atrophy, neuronal loss, and alterations. This investigation supports the utility of summary measurements of brain involvement in HIV infection. The findings also support assumptions concerning the enhanced sensitivity of DTI and MT to atrophic as well as alterations in the brain. These findings are broadly generalizable to brain imaging studies of physiological and pathological processes.
机译：扩散张量成像（DTI），磁化转移成像（MT）和自动脑容量测定用于总结大脑参与人类免疫缺陷病毒（HIV）感染的过程。多参数神经成像协议已在1.5实施。十分之一的艾滋病毒。 +和24个控件。基于DTI，MT和自动大脑容量计算了各种汇总参数。确定每种量度的差异幅度以及组间歧视。计算双变量相关性，并通过主因子分析检查成像参数之间的冗余度。在大多数措施中发现了显着或几乎显着的差异。指出了大的Cohen d效应尺寸，包括平均扩散率（MD），分数各向异性（FA），磁化传递比（MTR）和灰质体积分数（GM）。组间歧视对于FA和MTR而言是极好的，而MD则可以接受。所有成像参数之间的相关性可以通过三个因素来解释，这可能反映了总体萎缩，神经元丢失和改变。这项研究支持汇总测量艾滋病毒感染中的大脑参与度的实用性。这些发现还支持有关DTI和MT对萎缩以及脑部改变的敏感性增强的假设。这些发现可广泛推广到生理和病理过程的脑成像研究。

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