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首页> 外文期刊>Psychiatry Research. Neuroimaging >Detection of early changes in the parahippocampal and posterior cingulum bundles during mild cognitive impairment by using high-resolution multi-parametric diffusion tensor imaging
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Detection of early changes in the parahippocampal and posterior cingulum bundles during mild cognitive impairment by using high-resolution multi-parametric diffusion tensor imaging

机译：通过高分辨率多参数扩散张量成像检测轻度认知障碍期间海马旁和后扣带束的早期变化

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摘要

We aimed to determine alterations occurring in the parahippocampal cingulum bundle (PhC) and posterior cingulum bundle (PoC) in patients with mild cognitive impairment (MCI) through analysis of high-resolution multi-parametric diffusion tensor imaging (DTI). Participants comprised 41 patients with MCI (21 AD converters [MCI-C] and 20 non-converters IMCI-NCI), 20 patients with Alzheimer's disease (AD), and 26 healthy elderly subjects who underwent prospective examination with highresolution DTI. An atlas-based regions-of-interest (ROls) method calculated fractional anisotropy (FA), mean diffusivity (MD), axial diffusivity (DA), and radial diffusivity (DR) in the PhC and PoC. For the PhC. FA values showed significant decreases, and MD and DR values showed significantly increases, in the MCI-C and AD groups compared with the healthy controls, although the MCI-C and MCI-NC groups did not differ significantly in these metrics. Conversely, none of the diffusion metrics for the PoC showed a significant difference among the MCI groups and the control groups, although there were significant differences between the AD group and control groups. High-resolution multi-parametric Dfl analysis was able to detect substantial changes in diffusion anisotropy and diffusivity in the PhC of patients with MCI who were destined to convert to AD. (C) 2015 Elsevier Ireland Ltd. All rights reserved,
机译：我们旨在通过分析高分辨率多参数弥散张量成像（DTI）来确定轻度认知障碍（MCI）患者的海马旁突束（PhC）和后突突束（PoC）发生的变化。参加者包括41例MCI患者（21例AD转化者[MCI-C]和20例非转化者IMCI-NCI），20例阿尔茨海默氏病（AD）患者和26例接受了高分辨率DTI前瞻性检查的健康老年受试者。基于图集的感兴趣区域（ROls）方法计算了PhC和PoC中的分数各向异性（FA），平均扩散率（MD），轴向扩散率（DA）和径向扩散率（DR）。对于PhC。与健康对照组相比，MCI-C和AD组的FA值显着下降，MD和DR值显着增加，尽管MCI-C和MCI-NC组在这些指标上没有显着差异。相反，尽管AD组和对照组之间存在显着差异，但PoC的扩散指标均未在MCI组和对照组之间显示出显着差异。高分辨率多参数Dfl分析能够检测注定要转化为AD的MCI患者的PhC扩散各向异性和扩散率的实质性变化。 （C）2015 Elsevier Ireland Ltd.保留所有权利，

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