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Cerebral correlates of cognitive reserve

机译：认知储备的脑相关

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Cognitive reserve is a hypothetical concept introduced to explain discrepancies between severity of clinical dementia syndromes and the extent of dementia pathology. We examined cognitive reserve in a research programme that followed up a non-clinical sample born in 1921 or 1936 and IQ-tested age 11 years in 1932 or 1947. Structural MRI exams were acquired in about 50% of the sample from whom a subsample were recruited into an additional fMRI study. Here, we summarise findings from seven interrelated studies. These support an understanding of cognitive reserve as a balance between positive life course activity-driven experiences and the negative effects of brain pathologies including cerebrovascular disease and total and regional brain volume loss. Hypothesised structural equation models illustrate the relative causal effects of these positive and negative contributions. Cognitive reserve is considered in the context of choice of interventions to prevent dementia and the opposing effects of cerebrovascular disease and Alzheimer like brain appearances. Crown Copyright (C) 2015 Published by Elsevier Ireland Ltd. All rights reserved.
机译：认知储备是一个假想概念，旨在解释临床痴呆症综合症的严重程度与痴呆症病理程度之间的差异。我们在一项研究计划中检查了认知储备，该研究计划随访了1921年或1936年出生的非临床样本以及1932年或1947年进行IQ检验的11岁年龄。大约50％的样本中进行了结构MRI检查，其中子样本来自招募到其他功能磁共振成像研究中。在这里，我们总结了七个相关研究的发现。这些支持将认知储备理解为在积极的人生过程活动驱动的体验与脑部疾病（包括脑血管疾病）和总和局部脑容量损失的负面影响之间的平衡。假设结构方程模型说明了这些正面和负面影响的相对因果关系。在选择预防痴呆症以及脑血管疾病和脑血管疾病和阿尔茨海默氏病的相反作用的干预措施时，应考虑认知储备。 Crown版权所有（C）2015，由Elsevier Ireland Ltd.发布。保留所有权利。

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