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首页> 外文期刊>Psychiatry Research. Neuroimaging >Cocaine addiction: Diffusion tensor imaging study of the inferior frontal and anterior cingulate white matter
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Cocaine addiction: Diffusion tensor imaging study of the inferior frontal and anterior cingulate white matter

机译：可卡因成瘾：下额额叶和前扣带回白质的扩散张量成像研究

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Inferior frontal and anterior cingulate white matter integrity in 32 cocaine-dependent subjects was compared with that in 33 age-matched healthy control subjects. Diffusion tensor imaging data were acquired with a 1.5-T magnetic resonance imaging system. Cocaine-dependent subjects presented significantly lower fractional anisotropy values in inferior frontal white matter at the anterior-posterior commissure plane and higher anterior cingulate white matter values than control subjects. White matter integrity was also associated with impulsivity and motivation to change (Readiness to Change Questionnaire). These findings support the hypothesis that cocaine dependence involves a disruption of orbitofrontal connectivity and suggest that the anterior cingulate brain area might play a role in the motivation to change.
机译：比较了32名可卡因依赖受试者的额叶和扣带前白质完整性与33例年龄相匹配的健康对照受试者的差异。扩散张量成像数据是通过1.5 T磁共振成像系统获得的。与可卡因有关的受试者在前后连合平面的下部额叶白质中的分数各向异性值显着低于对照受试者，而前扣带状白质值较高。白质完整性还与冲动性和改变动机相关（《改变意愿调查表》）。这些发现支持了可卡因依赖涉及眶额连接性破坏的假说，并表明前扣带回大脑区域可能在改变动机中起作用。

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