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首页> 外文期刊>Psychiatry Research. Neuroimaging >Behavioral performance predicts grey matter reductions in the right inferior frontal gyrus in young adults with combined type ADHD
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Behavioral performance predicts grey matter reductions in the right inferior frontal gyrus in young adults with combined type ADHD

机译：行为表现预测合并多动症的年轻成年人右下额回的灰质减少

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Optimized voxel-based morphometry (VBM) was used in the present study to investigate morphometric differences between young adults with combined type Attention Deficit/Hyperactivity Disorder (ADHD) and a well-matched control group. Investigations examined differences on a between-group whole brain level, as well as how individual differences in behavioral performance predicted grey matter differences. Although a whole brain analysis revealed no significant differences between ADHD and control individuals, ADHD but not control individuals exhibited reduced grey matter volume in the right inferior frontal gyrus (rIFG), predicted by poorer behavioral performance on all three measures. A subsequent region-of-interest approach revealed lower grey matter volume in the rIFG in ADHD compared to control individuals. These results suggest that young adults with ADHD show morphometric differences in inferior prefrontal regions, as compared to controls. These morphometric differences are related to disruptions in performance on behavioral tasks that frequently have been reported to be affected in individuals with ADHD.
机译：在本研究中，使用了基于体素的最佳形态学（VBM），以研究注意力缺陷/多动症合并型（ADHD）的年轻成年人与匹配良好的对照组之间的形态学差异。研究调查了组间全脑水平的差异，以及行为表现的个体差异如何预测灰质差异。尽管全脑分析显示ADHD与对照个体之间无显着差异，但ADHD而非对照个体在右下额回（rIFG）中的灰质体积减少，这是由所有三种措施的行为表现较差所预测。随后的关注区域方法显示，与对照组相比，ADHD的rIFG中的灰质体积较低。这些结果表明，与对照组相比，患有ADHD的年轻人在前额下部区域表现出形态学差异。这些形态上的差异与行为任务的表现中断有关，据报道行为任务经常受到多动症患者的影响。

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