• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Psychiatry Research. Neuroimaging >Decreased regional homogeneity in insula and cerebellum: A resting-state fMRI study in patients with major depression and subjects at high risk for major depression
【24h】

Decreased regional homogeneity in insula and cerebellum: A resting-state fMRI study in patients with major depression and subjects at high risk for major depression

机译：岛状和小脑区域同质性降低：一项针对重度抑郁症患者和高危重度抑郁症患者的静止状态fMRI研究

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Functional disconnectivity during the resting state has been observed in subjects with major depressive disorder (MDD), and in subjects at high genetic risk for major depression during task performance. It is hypothesized that functional impairments in certain brain areas are present in patients with MDD and in their first-degree relatives. To test this hypothesis, an analysis of regional homogeneity (ReHo) of the whole brain was performed on 45 subjects. Compared with the control group, subjects with MDD and those at high risk for MDD exhibited significantly decreased ReHo in the right insula and in the left cerebellum. These abnormalities may play an important role in the pathophysiology of depression.Major depressive disorder (MDD) is characterized by cognitive impairments, functional disability and mortality, and affects 7%~11% of the general population. The pathophysiology of depression is unclear. Neurobiological diagnostic markers are not currently established, and the diagnosis of depression is dependent on clinical signs and symptoms.
机译：在患有重性抑郁症（MDD）的受试者以及在任务执行过程中患有严重抑郁症的遗传风险较高的受试者中，已经观察到了静止状态下的功能断开。假设MDD患者及其一级亲属存在某些大脑区域的功能障碍。为了验证该假设，对45位受试者进行了整个大脑区域同质性（ReHo）的分析。与对照组相比，MDD受试者和MDD高危受试者的右岛和左小脑的ReHo明显降低。这些异常可能在抑郁症的病理生理中起重要作用。重度抑郁症（MDD）的特征是认知障碍，功能障碍和死亡率，影响了7％〜11％的普通人群。抑郁症的病理生理学尚不清楚。神经生物学诊断标记目前尚未建立，抑郁症的诊断取决于临床体征和症状。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号