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首页> 外文期刊>Psychiatry Research. Neuroimaging >Grey matter volume reductions in the emotion network of patients with depression and coronary artery disease
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Grey matter volume reductions in the emotion network of patients with depression and coronary artery disease

机译:抑郁症和冠心病患者情感网络中灰质物质的减少

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Coronary Artery Disease (CAD) and Major Depressive Disorder (MDD) commonly co-occur and may be linked by a network of brain regions involved in emotion regulation, including the orbitofrontal cortex, amygdala/ parahippocamal region and insula. We hypothesized structural differences in this emotion network more prominently in CAD + MDD versus CAD and healthy control (CTRL) groups that do not involve depression-related emotion circuitry. In contrast, we hypothesized structural similarities between CAD + MDD and MDD groups, both involving depression-related circuitry. We obtained structural magnetic resonance imaging scans from age-matched consenting subjects (CAD + MDD, n = 12; CAD, n = 12; MDD, n = 19; CTRL, n = 17) and performed a region of interest analysis. We found decreased grey matter volumes in the bilateral orbitofrontal cortex, bilateral amygdala/parahippocampal gyrus and right, insula in CAD + MDD versus CTRL subjects and decreased grey matter volumes in the bilateral amygdala/parahippocampal regions in CAD + MDD versus CAD subjects. We found grey matter reductions in the right orbitofrontal cortex of CAD + MDD versus MDD subjects, and reductions in right insula of CAD versus CRTL subjects. Our results support that the network of brain regions involved in emotion regulation may be relevant to the relationship between CAD and MDD.
机译:冠状动脉疾病(CAD)和严重抑郁症(MDD)通常同时发生,并可能与涉及情绪调节的大脑区域网络(包括眶额叶皮层,杏仁核/副丘脑区和岛突)联系在一起。我们假设,在CAD + MDD中,这种情感网络的结构差异与不涉及抑郁症相关情感电路的CAD和健康对照组(CTRL)相比更为突出。相反,我们假设CAD + MDD和MDD组之间的结构相似性,都涉及与抑郁症相关的电路。我们从年龄匹配的受试者(CAD + MDD,n = 12; CAD,n = 12; MDD,n = 19; CTRL,n = 17)获得结构磁共振成像扫描,并进行了感兴趣区域分析。我们发现CAD + MDD与CTRL受试者的双眼眶额叶皮层,双边杏仁核/海马旁回和右,岛的灰质体积减少,以及CAD + MDD与CAD受试者的双侧杏仁核/海马旁区的灰质体积减少。我们发现,CAD + MDD相对于MDD受试者的眶眶额皮质皮层灰质减少,而CAD相对于CRTL受试者的右岛绝缘层减少。我们的结果支持涉及情绪调节的大脑区域网络可能与CAD和MDD之间的关系有关。

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