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首页> 外文期刊>Psychiatry Research. Neuroimaging >Effects of antidepressant treatment on N-acetyl aspartate and choline levels in the hippocampus and thalami of post-stroke depression patients: A study using 1H magnetic resonance spectroscopy
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Effects of antidepressant treatment on N-acetyl aspartate and choline levels in the hippocampus and thalami of post-stroke depression patients: A study using 1H magnetic resonance spectroscopy

机译：抗抑郁药对中风后抑郁症患者海马和丘脑中N-乙酰天门冬氨酸和胆碱水平的影响：1H磁共振波谱研究

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Previous studies in patients with a major depressive disorder show functional abnormalities in the medial frontal cortex. Functional and structural abnormalities in patients with post-stroke depression (PSD) are not well studied. The major goals of this study were to determine the biochemical abnormalities that occur in PSD and to assess the effect of antidepressants in patients with PSD at the biochemical level. We used magnetic resonance imaging to detect structural or functional abnormalities in PSD patients. In a prospective study, we included 30 patients with PSD and 20 age-matched subjects as controls. Magnetic resonance spectroscopy (MRS) of the brain was conducted in all subjects at the beginning of the study. Patients with PSD were treated with the antidepressant paroxetine (20-40 mg/days) for 6 months. After the 6-month period, all PSD subjects underwent MRS again. PSD patients were evaluated with the Hamilton Depression Scale (HAMD) both before and after treatment with the antidepressant. The mean age of the PSD patients was 70.0 +- 4.2 years and that of the controls was 67.2 +- 5.4 years. Before treatment, N-acetyl aspartate/creatine (NAA/Cr) ratios in the bilateral hippocampus and thalami were significantly lower in PSD patients than in controls. Choline/creatine (Cho/Cr) ratios were significantly higher in the bilateral hippocampus and left thalamus in PSD patients than in controls. The Cho/Cr ratios were significantly higher in the left thalamus than in the right in PSD patients. The HAMD scores were significantly correlated with the Cho/Cr ratios in the left and right hippocampus. Compared with PSD patients before antidepressant treatment, the PSD subjects after treatment had significantly higher NAA/Cr ratios in the left hippocampus and bilateral thalami. They had significantly lower Cho/Cr ratios in bilateral hippocampus and left thalamus. Our study suggests that metabolic abnormalities in the hippocampus and thalamus are implicated in PSD. Antidepressants may alter the local metabolic abnormalities in these areas.
机译：先前对重度抑郁症患者的研究表明内侧额叶皮质功能异常。中风后抑郁症（PSD）患者的功能和结构异常尚未得到很好的研究。这项研究的主要目的是确定PSD中发生的生化异常，并从生化水平评估PSD患者中抗抑郁药的作用。我们使用磁共振成像来检测PSD患者的结构或功能异常。在一项前瞻性研究中，我们纳入了30例PSD患者和20例年龄相匹配的受试者作为对照。在研究开始时，对所有受试者进行了大脑的磁共振波谱（MRS）。 PSD患者接受抗抑郁药帕罗西汀（20-40 mg /天）治疗6个月。在六个月的时间之后，所有PSD受试者都再次接受了MRS。在抗抑郁药治疗之前和之后，均用汉密尔顿抑郁量表（HAMD）对PSD患者进行评估。 PSD患者的平均年龄为70.0±4.2岁，而对照组的平均年龄为67.2±5.4岁。治疗前，PSD患者双侧海马和丘脑中N-乙酰天门冬氨酸/肌酸（NAA / Cr）的比率显着低于对照组。 PSD患者的双侧海马和左丘脑的胆碱/肌酸（Cho / Cr）比明显高于对照组。 PSD患者左丘脑的Cho / Cr比值明显高于右丘脑。 HAMD评分与左右海马体的Cho / Cr比值显着相关。与抗抑郁药治疗前的PSD患者相比，治疗后的PSD患者左海马和双侧丘脑中的NAA / Cr比值明显更高。他们在双侧海马和左丘脑的Cho / Cr比值显着降低。我们的研究表明，海马和丘脑的代谢异常与PSD有关。抗抑郁药可能会改变这些区域的局部代谢异常。

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