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首页> 外文期刊>Psychiatry Research. Neuroimaging >Brain magnetic resonance spectroscopy in obsessive-compulsive disorder: the importance of considering subclinical symptoms of anxiety and depression.
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Brain magnetic resonance spectroscopy in obsessive-compulsive disorder: the importance of considering subclinical symptoms of anxiety and depression.

机译：强迫症的脑磁共振波谱：考虑焦虑和抑郁的亚临床症状的重要性。

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摘要

Brain metabolite concentrations have recently been assessed in different cerebral regions presumably targeted in patients with obsessive-compulsive disorder (OCD) using magnetic resonance spectroscopy (MRS). However, results have been divergent. Possible confounding variables, such as the cerebral localisation of investigated regions and metabolites considered, as well as subclinical symptoms of anxiety and depression, could have affected these MRS profiles. The main goal of this study was to assess MRS metabolite differences between 13 individuals with OCD and 12 matched healthy controls in seven brain regions potentially involved in OCD. The secondary objective was to assess the relationships between levels of anxiety and depression and brain metabolite concentrations. No difference was found for N-acetylaspartate, glutamate-glutamine, myo-inositol (mI) and choline relative to creatine (Cr) concentration in either the left or right orbitofrontal area, left or right median temporal lobe, left or right thalamus or the anterior cingulate cortex. A significant negative correlation between the mI/Cr in the left orbitofrontal area and the severity of OCD symptomatology was observed while subclinical anxiety and depression were closely related to brain metabolite ratios. Thus, these subclinical symptoms, commonly associated with OCD, should be considered in assessing brain metabolite concentrations and may be central to the comprehension of this disorder.
机译：最近已经使用磁共振波谱法（MRS）对大概在强迫症（OCD）患者中不同脑区域的脑代谢物浓度进行了评估。但是，结果却有所不同。可能的混淆变量，例如所研究区域的脑部位置和所考虑的代谢物，以及焦虑和抑郁的亚临床症状，可能已经影响了这些MRS资料。这项研究的主要目标是评估13个患有强迫症的人与12个匹配的健康对照在7个可能参与强迫症的大脑区域之间的MRS代谢差异。次要目标是评估焦虑和抑郁水平与脑代谢产物浓度之间的关系。左或右眶额区，左或右颞中叶，左或右丘脑或左或右丘脑区的N-乙酰天门冬氨酸，谷氨酸-谷氨酰胺，肌醇（mI）和胆碱相对于肌酸（Cr）浓度均无差异。前扣带回皮层。观察到左眶额区的mI / Cr与OCD症状的严重程度之间存在显着的负相关，而亚临床焦虑和抑郁与脑代谢物比率密切相关。因此，这些通常与强迫症相关的亚临床症状应在评估脑代谢物浓度时加以考虑，并且可能是理解该疾病的关键。

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