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首页> 外文期刊>Psychiatry Research. Neuroimaging >Striatal volumes in pediatric bipolar patients with and without comorbid ADHD
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Striatal volumes in pediatric bipolar patients with and without comorbid ADHD

机译：有和没有合并多动症的小儿双相患者的纹状体体积

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The most prevalent comorbid disorder in pediatric bipolar disorder (BD) is attention-deficit/hyperactivity disorder (ADHD). As caudate volume abnormalities have been demonstrated in both BD and ADHD, this study sought to determine whether these findings could be attributed to separable effects from either diagnosis. High resolution anatomical magnetic resonance (MRI) images were obtained from youth in 4 groups: BD with comorbid ADHD (n= 17), BD without comorbid ADHD (n= 12), youth with ADHD alone (n= 11), and healthy control subjects (n= 24). Caudate, putamen, and globus pallidus volumes were manually traced for each subject using BrainImageJava software by a reliable rater blinded to diagnosis. There was a significant effect of diagnosis on striatal volumes, with ADHD associated with decreased caudate and putamen volumes, and BD associated with increased caudate, putamen, and globus pallidus volumes. Thus, the presence or absence of comorbid ADHD in patients with BD was associated with distinct alterations in caudate volumes, suggesting that these groups have different, but related, mechanisms of neuropathology.
机译：小儿双相情感障碍（BD）中最普遍的合并症是注意力缺陷/多动症（ADHD）。由于在BD和ADHD中均已显示出尾状体积异常，因此本研究试图确定这些发现是否可归因于任一诊断的可分离作用。从4组青年中获得高分辨率解剖磁共振（MRI）图像：BD合并共病多动症（n = 17），BD无合并症多动症（n = 12），仅ADHD合并青年（n = 11）和健康对照科目（n = 24）。通过对诊断无知的可靠评分者，使用BrainImageJava软件手动跟踪了每个受试者的尾状，壳状核和苍白球体积。诊断对纹状体容积有显着影响，ADHD与尾状核和壳状核的减少有关，而BD与尾状核，壳状核和苍白球的增加有关。因此，BD患者合并或不合并ADHD与尾状体容积的明显改变有关，表明这些组具有不同但相关的神经病理学机制。

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